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    Tmem170 transmembrane protein 170 [ Mus musculus (house mouse) ]

    Gene ID: 66817, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem170provided by MGI
    Official Full Name
    transmembrane protein 170provided by MGI
    Primary source
    MGI:MGI:106426
    See related
    Ensembl:ENSMUSG00000031953 AllianceGenome:MGI:106426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem170a; D8Bwg1414e; 9030409E16Rik
    Summary
    Predicted to be involved in endoplasmic reticulum tubular network organization; nuclear envelope organization; and nuclear pore complex assembly. Predicted to be located in nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMEM170A (transmembrane protein 170A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 5.1), placenta adult (RPKM 5.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 58.08 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112589670..112603378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111863038..111876746, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51589 Neighboring gene STARR-seq mESC enhancer starr_22714 Neighboring gene STARR-seq mESC enhancer starr_22715 Neighboring gene predicted gene, 39252 Neighboring gene craniofacial development protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6685 Neighboring gene STARR-positive B cell enhancer ABC_E6686 Neighboring gene STARR-positive B cell enhancer ABC_E5043 Neighboring gene STARR-seq mESC enhancer starr_22724 Neighboring gene STARR-seq mESC enhancer starr_22725 Neighboring gene carbohydrate sulfotransferase 5 Neighboring gene transmembrane protein 231 Neighboring gene predicted gene, 36531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 170A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025781.2 → NP_080057.1  transmembrane protein 170A

      See identical proteins and their annotated locations for NP_080057.1

      Status: VALIDATED

      Source sequence(s)
      AK018496
      Consensus CDS
      CCDS22681.1
      UniProtKB/Swiss-Prot
      A6H6Q8, Q9D342
      Related
      ENSMUSP00000034431.2, ENSMUST00000034431.3
      Conserved Domains (1) summary
      pfam10190
      Location:39 → 144
      Tmemb_170; Putative transmembrane protein 170

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112589670..112603378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531291.4 → XP_006531354.2  transmembrane protein 170A isoform X1

      Conserved Domains (1) summary
      pfam10190
      Location:39 → 121
      Tmemb_170; Putative transmembrane protein 170
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D342.1 GenPept UniProtKB/Swiss-Prot:Q9D342

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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