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    Fer1l5 fer-1-like family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679806, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fer1l5provided by RGD
    Official Full Name
    fer-1-like family member 5provided by RGD
    Primary source
    RGD:1583681
    See related
    Ensembl:ENSRNOG00000024201 AllianceGenome:RGD:1583681
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fer1l5-ps1
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including myeloid cell activation involved in immune response; negative regulation of phagocytosis; and plasma membrane organization. Predicted to be integral component of membrane. Predicted to be active in T-tubule and cytoplasmic vesicle. Orthologous to human FER1L5 (fer-1 like family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 40.5), Adrenal (RPKM 6.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q21
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46101798..46156483)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38605835..38661869)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (42943362..42998126)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554222 Neighboring gene neuralized E3 ubiquitin protein ligase 3 Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene lectin, mannose-binding 2-like Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T-tubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monocyte activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in T-tubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fer-1-like protein 5
    Names
    fer-1-like 5, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46101798..46156483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084527.2 → XP_038940455.1  fer-1-like protein 5 isoform X3

      Conserved Domains (9) summary
      cd04011
      Location:133 → 240
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1047 → 1182
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04037
      Location:1457 → 1580
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:1692 → 1824
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:661 → 733
      FerB; FerB (NUC096) domain
      pfam08151
      Location:245 → 278
      FerI; FerI (NUC094) domain
      pfam08165
      Location:585 → 635
      FerA; FerA (NUC095) domain
      pfam16165
      Location:1841 → 1956
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:2 → 100
      C2; C2 domain

    2. XM_017596789.3 → XP_017452278.1  fer-1-like protein 5 isoform X1

    3. XM_017596792.3 → XP_017452281.1  fer-1-like protein 5 isoform X4

    4. XM_039084528.2 → XP_038940456.1  fer-1-like protein 5 isoform X5

      Conserved Domains (6) summary
      cd04011
      Location:203 → 310
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1117 → 1252
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      pfam08150
      Location:731 → 803
      FerB; FerB (NUC096) domain
      pfam08151
      Location:315 → 348
      FerI; FerI (NUC094) domain
      pfam08165
      Location:655 → 705
      FerA; FerA (NUC095) domain
      cl14603
      Location:69 → 170
      C2; C2 domain

    5. XM_039084529.2 → XP_038940457.1  fer-1-like protein 5 isoform X7

      Conserved Domains (6) summary
      cd04011
      Location:203 → 310
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:1117 → 1252
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      pfam08150
      Location:731 → 803
      FerB; FerB (NUC096) domain
      pfam08151
      Location:315 → 348
      FerI; FerI (NUC094) domain
      pfam08165
      Location:655 → 705
      FerA; FerA (NUC095) domain
      cl14603
      Location:69 → 170
      C2; C2 domain

    6. XM_008767045.4 → XP_008765267.2  fer-1-like protein 5 isoform X2

      UniProtKB/TrEMBL
      D3ZU90

    7. XM_063268114.1 → XP_063124184.1  fer-1-like protein 5 isoform X6

    RNA

    1. XR_005489102.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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