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    MKRN1 makorin ring finger protein 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 475528, updated on 5-Mar-2024

    Summary

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    Gene symbol
    MKRN1
    Gene description
    makorin ring finger protein 1
    See related
    Ensembl:ENSCAFG00845031068
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (8429088..8450880)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (9352142..9373912)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (8292841..8314628)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (8379966..8401876)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (8224494..8246261)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene 40S ribosomal protein S27-like Neighboring gene U6 spliceosomal RNA Neighboring gene RAB19, member RAS oncogene family Neighboring gene solute carrier family 37 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase makorin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      8429088..8450880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038689099.1 → XP_038545027.1  E3 ubiquitin-protein ligase makorin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0L8R2, A0A8I3QBJ6
      Related
      ENSCAFP00845043438.1, ENSCAFT00845055230.1
      Conserved Domains (5) summary
      PHA03096
      Location:224 → 373
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:281 → 341
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:395 → 485
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18044
      Location:62 → 83
      zf-CCCH_4; CCCH-type zinc finger
      pfam18345
      Location:93 → 111
      zf_CCCH_4; Zinc finger domain

    2. XM_038689100.1 → XP_038545028.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L8R2
      Conserved Domains (4) summary
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214 → 274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:328 → 418
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:26 → 44
      zf_CCCH_4; Zinc finger domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      8379966..8401876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038497061.1 → XP_038352989.1  E3 ubiquitin-protein ligase makorin-1 isoform X1

    2. XM_038497062.1 → XP_038352990.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      Conserved Domains (4) summary
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214 → 274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:328 → 418
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:26 → 44
      zf_CCCH_4; Zinc finger domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      8224494..8246261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623380.1 → XP_038479308.1  E3 ubiquitin-protein ligase makorin-1 isoform X1

    2. XM_038623381.1 → XP_038479309.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      Conserved Domains (4) summary
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214 → 274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:328 → 418
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:26 → 44
      zf_CCCH_4; Zinc finger domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      8292841..8314628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559400.1 → XP_038415328.1  E3 ubiquitin-protein ligase makorin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0L8R2, A0A8C0MKB6

    2. XM_038559401.1 → XP_038415329.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L8R2
      Conserved Domains (4) summary
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214 → 274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:328 → 418
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:26 → 44
      zf_CCCH_4; Zinc finger domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9352142..9373912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_846671.6 → XP_851764.3  E3 ubiquitin-protein ligase makorin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0L8R2, A0A8P0S9K0
      Conserved Domains (5) summary
      PHA03096
      Location:222 → 371
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:279 → 339
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:393 → 483
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18044
      Location:60 → 81
      zf-CCCH_4; CCCH-type zinc finger
      pfam18345
      Location:91 → 109
      zf_CCCH_4; Zinc finger domain

    2. XM_038452589.1 → XP_038308517.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L8R2
      Conserved Domains (4) summary
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214 → 274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:328 → 418
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:26 → 44
      zf_CCCH_4; Zinc finger domain
    Nucleotide Protein
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