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    PDIA3 protein disulfide isomerase family A member 3 [ Gallus gallus (chicken) ]

    Gene ID: 373899, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PDIA3provided by CGNC
    Official Full Name
    protein disulfide isomerase family A member 3provided by CGNC
    Primary source
    CGNC:6325
    See related
    Ensembl:ENSGALG00010000039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    58kDa; ERp57; GRP58; 25D3-membrane-associated
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (20162030..20170918, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (20026359..20035248, complement)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene ras and EF-hand domain-containing protein-like Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2 Neighboring gene creatine kinase, mitochondrial 1B Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene microtubule associated protein 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein. Nemere I, et al. J Steroid Biochem Mol Biol, 2004 May. PMID 15225786
    2. Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells. Nemere I, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123837, Free PMC Article
    3. The 1,25D3-MARRS protein: contribution to steroid stimulated calcium uptake in chicks and rats. Nemere I. Steroids, 2005 May-Jun. PMID 15862830
    4. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article
    5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 1,25D3-MARRS has a role in steroid stimulated calcium uptake [review]
      Title: The 1,25D3-MARRS protein: contribution to steroid stimulated calcium uptake in chicks and rats.
    2. determination of link phosphate transport in the chick duodenum with the 1,25D(3)-MARRS protein and point to a previously uncharacterized role for this multifunctional protein class
      Title: Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells.
    3. identification and characterization of open coding region, signal peptides and translation product
      Title: Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein.
    4. 1,25D3-MARRS protein acts as an apparent membrane receptor for the steroid hormone 1,25-dihydroxyvitamin D3. Binding of ligand to 1,25D3-MARRS protein initiates signal transduction events leading to phosphate uptake and transport in intestine.
      Title: Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein disulfide-isomerase A3
    Names
    1,25D3-MARRS protein
    1,25D3-membrane-associated, rapid-response steroid-binding protein
    25D3-MARRS protein
    ER protein 57
    endoplasmic reticulum resident protein 57
    glucose regulated protein, 58kDa
    glucose regulated thiol oxidoreductase protein
    glucose-regulated thiol oxidoreductase 58 kDa protein
    rapid-response steroid-binding protein
    NP_989441.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204110.4 → NP_989441.1  protein disulfide-isomerase A3 precursor

      See identical proteins and their annotated locations for NP_989441.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000246
      UniProtKB/Swiss-Prot
      Q8JG64
      UniProtKB/TrEMBL
      A0A8V0WZA6
      Related
      ENSGALP00010000016.1, ENSGALT00010000040.1
      Conserved Domains (5) summary
      cd02995
      Location:375 → 478
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03069
      Location:133 → 238
      PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
      cd03073
      Location:242 → 355
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01130
      Location:25 → 483
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam00085
      Location:27 → 129
      Thioredoxin; Thioredoxin

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      20162030..20170918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      20026359..20035248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JG64.1 GenPept UniProtKB/Swiss-Prot:Q8JG64

    Gene LinkOut

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