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    cers5 ceramide synthase 5 [ Danio rerio (zebrafish) ]

    Gene ID: 323020, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cers5provided by ZNC
    Official Full Name
    ceramide synthase 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1740
    See related
    Ensembl:ENSDARG00000002365 AllianceGenome:ZFIN:ZDB-GENE-030131-1740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lass5; zgc:63908; wu:fb79b03
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane and nucleus. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including EVL; digestive system; immature eye; intermediate cell mass of mesoderm; and periderm. Orthologous to human CERS5 (ceramide synthase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (5757892..5821807, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (5728248..5791887, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene BCDIN3 domain containing Neighboring gene cytochrome c oxidase assembly factor COX14 Neighboring gene uncharacterized LOC103909525 Neighboring gene uncharacterized LOC103909524 Neighboring gene si:rp71-36a1.5 Neighboring gene zmp:0000001161

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family. Brondolin M, et al. Dev Dyn, 2013 Feb. PMID 23203913
    2. Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Zhang T, et al. Sci Rep, 2019 Dec 27. PMID 31882772, Free PMC Article
    3. The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. Mendelson K, et al. Elife, 2017 Sep 28. PMID 28956531, Free PMC Article
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ceramide synthase 5
    Names
    LAG1 homolog, ceramide synthase 5
    LAG1 longevity assurance homolog 5
    NP_955922.1
    XP_021324978.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199628.1 → NP_955922.1  ceramide synthase 5

      See identical proteins and their annotated locations for NP_955922.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053143
      UniProtKB/TrEMBL
      Q7T3F1
      Related
      ENSDARP00000002973.6, ENSDART00000011076.7
      Conserved Domains (2) summary
      cd00086
      Location:81 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:132 → 325
      TRAM_LAG1_CLN8; TLC domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      5757892..5821807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469303.2 → XP_021324978.1  ceramide synthase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PDT3
      Conserved Domains (2) summary
      cd00086
      Location:81 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:132 → 325
      TRAM_LAG1_CLN8; TLC domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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