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    RGN regucalcin [ Bos taurus (domestic cattle) ]

    Gene ID: 280910, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RGNprovided by VGNC
    Official Full Name
    regucalcinprovided by VGNC
    Primary source
    VGNC:VGNC:33907
    See related
    Ensembl:ENSBTAG00000046155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GNL
    Orthologs
    human mouse all
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    Genomic context

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    See RGN in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (85466174..85483079)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene jade family PHD finger 3 Neighboring gene 4-hydroxybenzoate polyprenyltransferase, mitochondrial-like Neighboring gene serine/threonine-protein phosphatase 2A catalytic subunit Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene NADH:ubiquinone oxidoreductase subunit B11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regucalcin expression in bovine tissues and its regulation by sex steroid hormones in accessory sex glands. Starvaggi Cucuzza L, et al. PLoS One, 2014. PMID 25415588, Free PMC Article
    2. The gene of Ca2+-binding protein regucalcin is highly conserved in vertebrate species. Misawa H, et al. Int J Mol Med, 2000 Aug. PMID 10891565
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables gluconolactonase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regucalcin
    Names
    RC
    SMP-30
    gluconolactonase
    regucalcin (senescence marker protein-30)
    senescence marker protein 30
    NP_776382.1
    XP_005228121.1
    XP_005228122.1
    XP_005228123.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173957.3 → NP_776382.1  regucalcin

      See identical proteins and their annotated locations for NP_776382.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000030
      UniProtKB/Swiss-Prot
      Q3ZBB2, Q9TTJ5
      Conserved Domains (3) summary
      cd05819
      Location:203 → 237
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:16 → 264
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:166 → 237
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      85466174..85483079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005228066.4 → XP_005228123.1  regucalcin isoform X2

      See identical proteins and their annotated locations for XP_005228123.1

      Conserved Domains (1) summary
      pfam08450
      Location:18 → 266
      SGL; SMP-30/Gluconolaconase/LRE-like region

    2. XM_005228065.5 → XP_005228122.1  regucalcin isoform X2

      See identical proteins and their annotated locations for XP_005228122.1

      Conserved Domains (1) summary
      pfam08450
      Location:18 → 266
      SGL; SMP-30/Gluconolaconase/LRE-like region

    3. XM_005228064.5 → XP_005228121.1  regucalcin isoform X1

      UniProtKB/TrEMBL
      A0A452DKN5
      Related
      ENSBTAP00000055515.3, ENSBTAT00000065105.3
      Conserved Domains (3) summary
      cd05819
      Location:227 → 261
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:40 → 288
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:190 → 261
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TTJ5.1 GenPept UniProtKB/Swiss-Prot:Q9TTJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials