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Rgn regucalcin [ Mus musculus (house mouse) ]

Gene ID: 19733, updated on 19-Mar-2019

Summary

Official Symbol
Rgnprovided by MGI
Official Full Name
regucalcinprovided by MGI
Primary source
MGI:MGI:108024
See related
Ensembl:ENSMUSG00000023070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GNL; SMP30; AI265316
Expression
Biased expression in liver E18 (RPKM 208.8), liver adult (RPKM 124.7) and 2 other tissues See more
Orthologs

Genomic context

See Rgn in Genome Data Viewer
Location:
X; X A1.3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (20549766..20562089)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (20126944..20139213)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene jade family PHD finger 3 Neighboring gene ubiquitin-like modifier activating enzyme 3 pseudogene Neighboring gene upregulated during skeletal muscle growth 5 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene RNA binding motif protein 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
 
gluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gluconolactonase activity IDA
Inferred from Direct Assay
more info
PubMed 
gluconolactonase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
L-ascorbic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-ascorbic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of RNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
negative regulation of leucine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium-transporting ATPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dUTP diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regucalcin
Names
RC
SMP-30
gluconolactonase
senescence marker protein 30
NP_033086.1
XP_006527635.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009060.2NP_033086.1  regucalcin

    See identical proteins and their annotated locations for NP_033086.1

    Status: PROVISIONAL

    Source sequence(s)
    AL672073
    Consensus CDS
    CCDS30043.1
    UniProtKB/Swiss-Prot
    Q64374
    Related
    ENSMUSP00000023832.6, ENSMUST00000023832.6
    Conserved Domains (3) summary
    cd05819
    Location:203237
    NHL; NHL repeat [structural motif]
    pfam08450
    Location:16264
    SGL; SMP-30/Gluconolaconase/LRE-like region
    cl18310
    Location:166237
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    20549766..20562089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527572.3XP_006527635.1  regucalcin isoform X1

    See identical proteins and their annotated locations for XP_006527635.1

    UniProtKB/Swiss-Prot
    Q64374
    Conserved Domains (3) summary
    cd05819
    Location:203237
    NHL; NHL repeat [structural motif]
    pfam08450
    Location:16264
    SGL; SMP-30/Gluconolaconase/LRE-like region
    cl18310
    Location:166237
    NHL; NHL repeat unit of beta-propeller proteins
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