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    Hsd17b1 hydroxysteroid 17-beta dehydrogenase 1 [ Heterocephalus glaber (naked mole-rat) ]

    Gene ID: 101720493, updated on 19-Jun-2024

    Summary

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    Gene symbol
    Hsd17b1
    Gene description
    hydroxysteroid 17-beta dehydrogenase 1
    Locus tag
    GW7_06849
    See related
    Ensembl:ENSHGLG00000013516
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Heterocephalus glaber
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624795.1 (1551311..1553432, complement)

    NW_004624795.1Genomic Context describing neighboring genes Neighboring gene PSMC3 interacting protein Neighboring gene MAX dimerization protein MLX Neighboring gene Coenzyme A synthase Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene ATPase H+ transporting V0 subunit a1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004624795 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    estradiol 17-beta-dehydrogenase 1
    Names
    Estradiol 17-beta-dehydrogenase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HetGla_female_1.0 Primary Assembly

    Genomic

    1. NW_004624795.1 Reference HetGla_female_1.0 Primary Assembly

      Range
      1551311..1553432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021240070.1 → XP_021095729.1  estradiol 17-beta-dehydrogenase 1 isoform X2

      Conserved Domains (1) summary
      cl25409
      Location:7 → 91
      SDR; Short-chain dehydrogenases/reductases (SDR)

    2. XM_021240071.1 → XP_021095730.1  estradiol 17-beta-dehydrogenase 1 isoform X4

      Conserved Domains (1) summary
      cl25409
      Location:7 → 253
      SDR; Short-chain dehydrogenases/reductases (SDR)

    3. XM_004859336.2 → XP_004859393.1  estradiol 17-beta-dehydrogenase 1 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:7 → 91
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_021240072.1 → XP_021095731.1  estradiol 17-beta-dehydrogenase 1 isoform X5

      Conserved Domains (1) summary
      cl25409
      Location:7 → 207
      SDR; Short-chain dehydrogenases/reductases (SDR)

    5. XM_004859337.2 → XP_004859394.1  estradiol 17-beta-dehydrogenase 1 isoform X3

      See identical proteins and their annotated locations for XP_004859394.1

      UniProtKB/TrEMBL
      G5B0J6
      Related
      ENSHGLP00000018861.1, ENSHGLT00000019050.1
      Conserved Domains (2) summary
      pfam00106
      Location:8 → 195
      adh_short; short chain dehydrogenase
      cl21454
      Location:7 → 263
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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