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    Lck LCK proto-oncogene, Src family tyrosine kinase [ Heterocephalus glaber (naked mole-rat) ]

    Gene ID: 101714396, updated on 11-Apr-2024

    Summary

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    Gene symbol
    Lck
    Gene description
    LCK proto-oncogene, Src family tyrosine kinase
    Locus tag
    GW7_09311
    See related
    Ensembl:ENSHGLG00000014704
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Heterocephalus glaber
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624764.1 (15469582..15495351)

    NW_004624764.1Genomic Context describing neighboring genes Neighboring gene doublecortin domain containing 2B Neighboring gene IQ motif containing C Neighboring gene transmembrane protein 234 Neighboring gene family with sequence similarity 167 member B Neighboring gene histone deacetylase 1 Neighboring gene MARCKS like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004624764 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Lck
    Names
    Proto-oncogene tyrosine-protein kinase LCK
    lymphocyte-specific protein tyrosine kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HetGla_female_1.0 Primary Assembly

    Genomic

    1. NW_004624764.1 Reference HetGla_female_1.0 Primary Assembly

      Range
      15469582..15495351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013074412.2 → XP_012929866.1  tyrosine-protein kinase Lck isoform X2

      See identical proteins and their annotated locations for XP_012929866.1

      UniProtKB/TrEMBL
      G5BU89
      Conserved Domains (3) summary
      cd10362
      Location:123 → 223
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:65 → 118
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:237 → 500
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

    2. XM_013074413.2 → XP_012929867.1  tyrosine-protein kinase Lck isoform X2

      See identical proteins and their annotated locations for XP_012929867.1

      UniProtKB/TrEMBL
      G5BU89
      Related
      ENSHGLP00000020567.1, ENSHGLT00000020769.1
      Conserved Domains (3) summary
      cd10362
      Location:123 → 223
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:65 → 118
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:237 → 500
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

    3. XM_021263262.1 → XP_021118921.1  tyrosine-protein kinase Lck isoform X1

      Related
      ENSHGLP00000020568.1, ENSHGLT00000020770.1
      Conserved Domains (3) summary
      cd10362
      Location:135 → 235
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:77 → 130
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:249 → 512
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

    4. XM_021263263.1 → XP_021118922.1  tyrosine-protein kinase Lck isoform X2

      UniProtKB/TrEMBL
      G5BU89
      Conserved Domains (3) summary
      cd10362
      Location:123 → 223
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:65 → 118
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:237 → 500
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    Nucleotide Protein
    Heading Accession and Version

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