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Lck lymphocyte protein tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 16818, updated on 9-Sep-2018

Summary

Official Symbol
Lckprovided by MGI
Official Full Name
lymphocyte protein tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96756
See related
Ensembl:ENSMUSG00000000409 Vega:OTTMUSG00000009667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lsk; Lskt; Hck-3; p56Lck; p56<lck>
Expression
Biased expression in thymus adult (RPKM 430.2), spleen adult (RPKM 43.4) and 1 other tissue See more
Orthologs

Genomic context

See Lck in Genome Data Viewer
Location:
4 D2.2; 4 63.26 cM
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (129548344..129573641, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (129225588..129250885, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene MARCKS-like 1 Neighboring gene histone deacetylase 1 Neighboring gene microRNA 8119 Neighboring gene family with sequence similarity 167, member B Neighboring gene eukaryotic translation initiation factor 3, subunit I

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (3) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
CD4 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
 
CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
antigen binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of uterine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of regulatory T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
response to metal ion ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
immunological synapse ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
pericentriolar material ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic specialization, intracellular component ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase LCK
Names
leukocyte C-terminal Src kinase
lymphocyte cell-specific protein-tyrosine kinase
NP_001155904.1
NP_001155905.1
NP_034823.1
XP_006502881.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162432.1NP_001155904.1  proto-oncogene tyrosine-protein kinase LCK isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA124492, AL606921, BQ563042, BY087238, CA577097, CX217876
    Consensus CDS
    CCDS51306.1
    UniProtKB/TrEMBL
    E9Q696
    Related
    ENSMUSP00000125777.1, ENSMUST00000167288.7
    Conserved Domains (4) summary
    cd10362
    Location:134234
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:76129
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:248511
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:256505
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001162433.1NP_001155905.1  proto-oncogene tyrosine-protein kinase LCK isoform b

    See identical proteins and their annotated locations for NP_001155905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AA124492, AL606921, BQ563042, BY100584, CA577097, CX217876
    Consensus CDS
    CCDS18697.1
    UniProtKB/Swiss-Prot
    P06240
    Related
    ENSMUSP00000099656.1, OTTMUSP00000010178, ENSMUST00000102596.7, OTTMUST00000022307
    Conserved Domains (4) summary
    cd10362
    Location:123223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:245494
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_010693.3NP_034823.1  proto-oncogene tyrosine-protein kinase LCK isoform b

    See identical proteins and their annotated locations for NP_034823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AA124492, AL606921, BQ563042, CA577097, CX217876
    Consensus CDS
    CCDS18697.1
    UniProtKB/Swiss-Prot
    P06240
    Related
    ENSMUSP00000066209.4, OTTMUSP00000010179, ENSMUST00000067240.10, OTTMUST00000022308
    Conserved Domains (4) summary
    cd10362
    Location:123223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:245494
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    129548344..129573641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502818.3XP_006502881.1  proto-oncogene tyrosine-protein kinase LCK isoform X1

    See identical proteins and their annotated locations for XP_006502881.1

    UniProtKB/Swiss-Prot
    P06240
    Conserved Domains (4) summary
    cd10362
    Location:123223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
    pfam07714
    Location:245494
    Pkinase_Tyr; Protein tyrosine kinase

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187023.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    1147929..1173325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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