Lck lymphocyte protein tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lckprovided by MGI
Official Full Name: lymphocyte protein tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:96756
See related: Ensembl:ENSMUSG00000000409 Vega:OTTMUSG00000009667
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lsk; Lskt; Hck-3; p56Lck; p56<lck>
Expression: Biased expression in thymus adult (RPKM 430.2), spleen adult (RPKM 43.4) and 1 other tissue See more
Orthologs: human all

Genomic context

Location:: 4 D2.2; 4 63.26 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	4	NC_000070.6 (129548344..129573641, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	4	NC_000070.5 (129225588..129250885, complement)

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck complex of protein kinase Ctheta; (PKCtheta;), which serves as a key effector kinase in the CD28 signaling pathway.
Title: Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.
Title: A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice)
Title: lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.
this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity
Title: Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.
this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development
Title: T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages.
Aurora A inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck active during T-cell activation.
Title: Aurora A drives early signalling and vesicle dynamics during T-cell activation.
essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells
Title: Regulation of T cell development by c-Cbl: essential role of Lck.
Lck-Dlx5 mice develop T-ALLs that consistently acquire overexpression of Myc and activation of Akt.
Title: Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.
Lck-CD8 interaction is required for initial CD8 recruitment.
Title: Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Title: The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (3)

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CD28 co-stimulation, organism-specific biosystem (from REACTOME)
CD28 co-stimulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CD28 dependent PI3K/Akt signaling, organism-specific biosystem (from REACTOME)
CD28 dependent PI3K/Akt signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
CD28 dependent Vav1 pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
CTLA4 inhibitory signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Downstream TCR signaling, organism-specific biosystem (from REACTOME)
Downstream TCR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
Fc epsilon receptor (FCERI) signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
GPVI-mediated activation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
Generation of second messenger molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
Inflammatory Response Pathway, organism-specific biosystem
Inflammatory Response Pathway
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
Interleukin-2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
NF-kappa B signaling pathway, conserved biosystem (from KEGG)
NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Negative regulation of the PI3K/AKT network, organism-specific biosystem (from REACTOME)
Negative regulation of the PI3K/AKT network, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
PD-1 signaling, organism-specific biosystem (from REACTOME)
PD-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, organism-specific biosystem (from REACTOME)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Primary immunodeficiency, organism-specific biosystem (from KEGG)
Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
Primary immunodeficiency, conserved biosystem (from KEGG)
Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
Regulation of KIT signaling, organism-specific biosystem (from REACTOME)
Regulation of KIT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
TCR signaling, organism-specific biosystem (from REACTOME)
TCR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Th17 cell differentiation, organism-specific biosystem (from KEGG)
Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Th17 cell differentiation, conserved biosystem (from KEGG)
Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemcomputationally inferred pathway (not manually curated)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lck (e-PCR), detects polymorphism
- UniSTS:526087

M12056 (e-PCR)
- UniSTS:159298

D4Mit203 (e-PCR), detects polymorphism
- UniSTS:116302

X03533 (e-PCR)
- UniSTS:125781

Lck (e-PCR), detects polymorphism
- UniSTS:143761

Lck (e-PCR), detects polymorphism
- UniSTS:143762

PMC166405P2 (e-PCR)
- UniSTS:271589

Homology

Homologs of the Lck gene: The Lck gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 218 organisms have orthologs with human gene Lck
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
ATPase binding	ISO Inferred from Sequence Orthology more info
CD4 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
CD4 receptor binding	ISO Inferred from Sequence Orthology more info
CD8 receptor binding	ISO Inferred from Sequence Orthology more info
SH2 domain binding	ISO Inferred from Sequence Orthology more info
T cell receptor binding	ISO Inferred from Sequence Orthology more info
antigen binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info
protein antigen binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein phosphatase binding	ISO Inferred from Sequence Orthology more info
protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
protein-containing complex binding	ISO Inferred from Sequence Orthology more info
signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
T cell differentiation	ISO Inferred from Sequence Orthology more info
activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
positive regulation of gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
positive regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
regulation of regulatory T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
response to drug	ISO Inferred from Sequence Orthology more info
response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
response to metal ion	ISO Inferred from Sequence Orthology more info
transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
endocytic vesicle	ISO Inferred from Sequence Orthology more info
extrinsic component of cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glutamatergic synapse	ISO Inferred from Sequence Orthology more info
immunological synapse	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
membrane raft	ISO Inferred from Sequence Orthology more info
pericentriolar material	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
postsynaptic specialization, intracellular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase LCK

Names: leukocyte C-terminal Src kinase; lymphocyte cell-specific protein-tyrosine kinase

NP_001155904.1

EC 2.7.10.2

NP_001155905.1

EC 2.7.10.2

NP_034823.1

EC 2.7.10.2

XP_006502881.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162432.1 → NP_001155904.1 proto-oncogene tyrosine-protein kinase LCK isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (a).

Source sequence(s)

AA124492, AL606921, BQ563042, BY087238, CA577097, CX217876

Consensus CDS

CCDS51306.1

UniProtKB/TrEMBL

E9Q696

Related

ENSMUSP00000125777.1, ENSMUST00000167288.7

Conserved Domains (4) summary

cd10362
Location:134 → 234

SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)

cd12005
Location:76 → 129

SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase

cd05067
Location:248 → 511

PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

pfam07714
Location:256 → 505

Pkinase_Tyr; Protein tyrosine kinase
NM_001162433.1 → NP_001155905.1 proto-oncogene tyrosine-protein kinase LCK isoform b

See identical proteins and their annotated locations for NP_001155905.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AA124492, AL606921, BQ563042, BY100584, CA577097, CX217876

Consensus CDS

CCDS18697.1

UniProtKB/Swiss-Prot

P06240

Related

ENSMUSP00000099656.1, OTTMUSP00000010178, ENSMUST00000102596.7, OTTMUST00000022307

Conserved Domains (4) summary

cd10362
Location:123 → 223

SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)

cd12005
Location:65 → 118

SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase

cd05067
Location:237 → 500

PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

pfam07714
Location:245 → 494

Pkinase_Tyr; Protein tyrosine kinase
NM_010693.3 → NP_034823.1 proto-oncogene tyrosine-protein kinase LCK isoform b

See identical proteins and their annotated locations for NP_034823.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AA124492, AL606921, BQ563042, CA577097, CX217876

Consensus CDS

CCDS18697.1

UniProtKB/Swiss-Prot

P06240

Related

ENSMUSP00000066209.4, OTTMUSP00000010179, ENSMUST00000067240.10, OTTMUST00000022308

Conserved Domains (4) summary

cd10362
Location:123 → 223

SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)

cd12005
Location:65 → 118

SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase

cd05067
Location:237 → 500

PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

pfam07714
Location:245 → 494

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38.p4 C57BL/6J

Range

129548344..129573641 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502818.3 → XP_006502881.1 proto-oncogene tyrosine-protein kinase LCK isoform X1

See identical proteins and their annotated locations for XP_006502881.1

UniProtKB/Swiss-Prot

P06240

Conserved Domains (4) summary

cd10362
Location:123 → 223

SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)

cd12005
Location:65 → 118

SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase

cd05067
Location:237 → 500

PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

pfam07714
Location:245 → 494

Pkinase_Tyr; Protein tyrosine kinase