Shc2 SHC adaptor protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shc2provided by RGD
Official Full Name: SHC adaptor protein 2provided by RGD
Primary source: RGD:1307137
See related: Ensembl:ENSRNOG00000008030 AllianceGenome:RGD:1307137
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Orthologous to human SHC2 (SHC adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 53.8), Brain (RPKM 49.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10717320..10739539)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (10066705..10088926)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12948952..12971174)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data show that the regulation of Shc mRNAs in senescence is region as well as isoform specific
Title: Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129511 (e-PCR)
- UniSTS:212814

RH128100 (e-PCR)
- UniSTS:211408

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SHC-transforming protein 2

Names: SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; protein Sck; src homology 2 domain-containing transforming protein C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108065.1 → NP_001101535.1 SHC-transforming protein 2

See identical proteins and their annotated locations for NP_001101535.1

Status: PROVISIONAL

Source sequence(s)

CH474029

UniProtKB/Swiss-Prot

O70142

UniProtKB/TrEMBL

A6K8Z6

Related

ENSRNOP00000010714.5, ENSRNOT00000010714.6

Conserved Domains (2) summary

cd09925
Location:470 → 573

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:116 → 285

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain