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Shc2 SHC (Src homology 2 domain containing) transforming protein 2 [ Mus musculus (house mouse) ]

Gene ID: 216148, updated on 7-Sep-2023

Summary

Official Symbol
Shc2provided by MGI
Official Full Name
SHC (Src homology 2 domain containing) transforming protein 2provided by MGI
Primary source
MGI:MGI:106180
See related
Ensembl:ENSMUSG00000020312 AllianceGenome:MGI:106180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCK; Sli; ShcB; 6720466E06
Summary
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including epidermis; liver; nervous system; sensory organ; and skeleton. Orthologous to human SHC2 (SHC adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 14.0), whole brain E14.5 (RPKM 11.3) and 19 other tissues See more
Orthologs
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Genomic context

See Shc2 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79453768..79473752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79617934..79637918, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule associated protein 2 Neighboring gene predicted gene, 51808 Neighboring gene C2 calcium-dependent domain containing 4C Neighboring gene CIMAP1 family member D Neighboring gene mucosal vascular addressin cell adhesion molecule 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SHC-transforming protein 2
Names
SH2 domain protein C2
SHC-transforming protein B
protein Sck
protein Sli
src homology 2 domain-containing-transforming protein C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024539.1NP_001019710.1  SHC-transforming protein 2

    See identical proteins and their annotated locations for NP_001019710.1

    Status: VALIDATED

    Source sequence(s)
    AK032878, BB646065, BC059866
    Consensus CDS
    CCDS48620.1
    UniProtKB/Swiss-Prot
    Q8BMC3
    UniProtKB/TrEMBL
    E9QLZ0
    Related
    ENSMUSP00000020564.7, ENSMUST00000020564.7
    Conserved Domains (2) summary
    cd09925
    Location:470573
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:116285
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79453768..79473752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)