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    slit2 slit guidance ligand 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100492007, updated on 25-Apr-2024

    Summary

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    Official Symbol
    slit2provided by Xenbase
    Official Full Name
    slit guidance ligand 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-1004410
    See related
    Ensembl:ENSXETG00000020473
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    slil3; slit-2
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (29619144..29823377)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (22695527..22897857, complement)

    Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene non-SMC condensin I complex subunit G Neighboring gene ligand dependent nuclear receptor corepressor like Neighboring gene microRNA mir-218-1 Neighboring gene parkin coregulated like Neighboring gene Kv channel interacting protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    slit homolog 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      29619144..29823377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031895351.1 → XP_031751211.1  slit homolog 2 protein isoform X5

      UniProtKB/TrEMBL
      A0A6I8SHG2, A0A6I8SZ86
      Related
      ENSXETP00000098971.2, ENSXETT00000080415.2
      Conserved Domains (8) summary
      TIGR00864
      Location:837 → 1018
      PCC; polycystin cation channel protein
      smart00013
      Location:36 → 67
      LRRNT; Leucine rich repeat N-terminal domain
      smart00282
      Location:1197 → 1330
      LamG; Laminin G domain
      cd00054
      Location:1090 → 1126
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00033
      Location:46 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:492 → 864
      internalin_A; class 1 internalin InlA
      pfam00008
      Location:1139 → 1168
      EGF; EGF-like domain
      pfam13855
      Location:783 → 842
      LRR_8; Leucine rich repeat

    2. XM_031895349.1 → XP_031751209.1  slit homolog 2 protein isoform X1

      UniProtKB/TrEMBL
      A0A6I8R7M7, A0A8J1J024
      Conserved Domains (9) summary
      TIGR00864
      Location:837 → 1018
      PCC; polycystin cation channel protein
      smart00013
      Location:36 → 67
      LRRNT; Leucine rich repeat N-terminal domain
      smart00282
      Location:1197 → 1330
      LamG; Laminin G domain
      cd00054
      Location:1090 → 1126
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00033
      Location:46 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:492 → 864
      internalin_A; class 1 internalin InlA
      pfam00008
      Location:1139 → 1168
      EGF; EGF-like domain
      pfam13855
      Location:783 → 842
      LRR_8; Leucine rich repeat
      cl21545
      Location:1482 → 1542
      GHB_like; Glycoprotein hormone beta chain homologues

    3. XM_012955706.3 → XP_012811160.1  slit homolog 2 protein isoform X2

      UniProtKB/TrEMBL
      A0A6I8R7M7, A0A8J0S6N3
      Related
      ENSXETP00000081607.2, ENSXETT00000084346.2
      Conserved Domains (12) summary
      smart00013
      Location:36 → 67
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:860 → 908
      LRRCT; Leucine rich repeat C-terminal domain
      smart00179
      Location:999 → 1030
      EGF_CA; Calcium-binding EGF-like domain
      smart00282
      Location:1193 → 1326
      LamG; Laminin G domain
      cd00054
      Location:1086 → 1122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:68 → 223
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:46 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:1135 → 1164
      EGF; EGF-like domain
      pfam12799
      Location:333 → 373
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:778 → 838
      LRR_8; Leucine rich repeat
      cl15307
      Location:218 → 253
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21545
      Location:1478 → 1538
      GHB_like; Glycoprotein hormone beta chain homologues

    4. XM_031895350.1 → XP_031751210.1  slit homolog 2 protein isoform X3

      UniProtKB/TrEMBL
      A0A6I8PUS8, A0A8J1J2E9
      Conserved Domains (9) summary
      TIGR00864
      Location:837 → 1018
      PCC; polycystin cation channel protein
      smart00013
      Location:36 → 67
      LRRNT; Leucine rich repeat N-terminal domain
      smart00282
      Location:1188 → 1321
      LamG; Laminin G domain
      cd00054
      Location:1081 → 1117
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00033
      Location:46 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:492 → 864
      internalin_A; class 1 internalin InlA
      pfam00008
      Location:1130 → 1159
      EGF; EGF-like domain
      pfam13855
      Location:783 → 842
      LRR_8; Leucine rich repeat
      cl21545
      Location:1473 → 1533
      GHB_like; Glycoprotein hormone beta chain homologues

    5. XM_002936715.5 → XP_002936761.2  slit homolog 2 protein isoform X4

      UniProtKB/TrEMBL
      A0A6I8PUS8, A0A8J0QRS5
      Related
      ENSXETP00000064289.2, ENSXETT00000103645.2
      Conserved Domains (10) summary
      TIGR00864
      Location:833 → 1014
      PCC; polycystin cation channel protein
      smart00013
      Location:36 → 67
      LRRNT; Leucine rich repeat N-terminal domain
      smart00282
      Location:1184 → 1317
      LamG; Laminin G domain
      COG4886
      Location:59 → 412
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00054
      Location:1077 → 1113
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00033
      Location:46 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:1126 → 1155
      EGF; EGF-like domain
      pfam13855
      Location:779 → 838
      LRR_8; Leucine rich repeat
      NF033189
      Location:488 → 860
      internalin_A; class 1 internalin InlA
      cl21545
      Location:1469 → 1529
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein Strain
    Heading Accession and Version

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