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SLIT2 slit guidance ligand 2 [ Homo sapiens (human) ]

Gene ID: 9353, updated on 13-Jan-2019

Summary

Official Symbol
SLIT2provided by HGNC
Official Full Name
slit guidance ligand 2provided by HGNC
Primary source
HGNC:HGNC:11086
See related
Ensembl:ENSG00000145147 MIM:603746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLIL3; Slit-2
Summary
This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in lung (RPKM 13.1), adrenal (RPKM 9.9) and 21 other tissues See more
Orthologs

Genomic context

See SLIT2 in Genome Data Viewer
Location:
4p15.31
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (20251905..20620561)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (20254566..20622184)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374513 Neighboring gene uncharacterized LOC105374514 Neighboring gene SLIT2 intronic transcript 1 Neighboring gene microRNA 218-1 Neighboring gene uncharacterized LOC105374515 Neighboring gene parkin coregulated like Neighboring gene potassium voltage-gated channel interacting protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 dendritic cell-to-T cell transmission is inhibited by the presence of recombinant, extracellular Slit2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced ROBO1-actin association PubMed
env The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced actin polymerization in T cells PubMed
env The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced phosphorylation of both LIMK1 and cofilin PubMed
env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
env Inhibition of M-tropic HIV-1 gp120-induced transendothelial migration by SLIT2N involves SLIT2N-mediated enhancement of co-localization of Robo1 with WASp and LSP1 in immature monocyte-derived dendritic cells PubMed
env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced association of LSP1, Wiskott-Aldrich Syndrome protein (WASp), Actin-Related Protein 2/3 (Arp2/3), and beta-actin in immature monocyte-derived dendritic cells PubMed
env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induces transendothelial migration and podosome formation in immature monocyte-derived dendritic cells PubMed
env SLIT2 inhibits HIV-1-induced lymphatic hyperpermeability by blocking the interaction between Robo4 and integrin alpha5beta1 in human lymphatic endothelial cells PubMed
env SLIT2 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells PubMed
env HIV-1 gp120 modulates the expression of SLIT2 in human lymphatic endothelial cells PubMed
Vif vif HIV-1 Vif upregulates the expression of slit homolog 2 (SLIT2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activation of Rac, organism-specific biosystem (from REACTOME)
    Activation of Rac, organism-specific biosystemA low level of Rac activity is essential to maintain axon outgrowth and Robo activation recruits Sos, a dual specificity GEF to the plasma membrane via Dock to activate Rac during midline repulsion.
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
    Glypican 1 network, organism-specific biosystem
    Glypican 1 network
  • Inactivation of Cdc42 and Rac, organism-specific biosystem (from REACTOME)
    Inactivation of Cdc42 and Rac, organism-specific biosystemRho family GTPases including Rac, Rho, and Cdc42 are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed...
  • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
    Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
  • Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystem (from REACTOME)
    Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystemCommissural axons project to the floor plate, attracted by the interaction of their DCC receptors with netrin1 produced by floor plate cells. The axons are insensitive to the repulsive action of slit...
  • Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
    Role of Abl in Robo-Slit signaling, organism-specific biosystemAbl plays a dual role in the Robo pathway. As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed ba...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Roundabout binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
laminin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
proteoglycan binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Roundabout signaling pathway IC
Inferred by Curator
more info
PubMed 
Roundabout signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
aortic valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process involved in luteolysis IEP
Inferred from Expression Pattern
more info
PubMed 
axon extension involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
 
branching morphogenesis of an epithelial tube IDA
Inferred from Direct Assay
more info
PubMed 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to heparin IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
NOT chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA
Inferred from Direct Assay
more info
PubMed 
chemorepulsion involved in postnatal olfactory bulb interneuron migration IDA
Inferred from Direct Assay
more info
PubMed 
corticospinal neuron axon guidance through spinal cord IMP
Inferred from Mutant Phenotype
more info
PubMed 
induction of negative chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
motor neuron axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
negative chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chemokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mononuclear cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axonogenesis TAS
Traceable Author Statement
more info
PubMed 
pulmonary valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cortisol IEP
Inferred from Expression Pattern
more info
PubMed 
retinal ganglion cell axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047105.1 RefSeqGene

    Range
    4981..373637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001289135.2NP_001276064.1  slit homolog 2 protein isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains one alternate in-frame exon and lacks one alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AA489463, AC021118, AC096718, AF133270, AK126459, BC143978, BF112143, BI494498, BM474839, CV370469, DA721496, DB207352
    Consensus CDS
    CCDS75110.1
    UniProtKB/Swiss-Prot
    O94813
    Related
    ENSP00000422261.1, ENST00000503837.5
    Conserved Domains (10) summary
    smart00013
    Location:2758
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:855904
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:11791312
    LamG; Laminin G domain
    cd00054
    Location:10721108
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:847859
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3856
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:328368
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:773833
    LRR_8; Leucine rich repeat
    cl15307
    Location:660709
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. NM_001289136.2NP_001276065.1  slit homolog 2 protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001276065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AA489463, AC021118, AC096718, AK126459, BC143978, BF112143, BI494498, BM474839, CV370469, DA721496, DB207352
    Consensus CDS
    CCDS75111.1
    UniProtKB/Swiss-Prot
    O94813
    Related
    ENSP00000427548.1, ENST00000503823.5
    Conserved Domains (10) summary
    smart00013
    Location:2758
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:851900
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:11751308
    LamG; Laminin G domain
    cd00054
    Location:10681104
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:843855
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3856
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:324364
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:769829
    LRR_8; Leucine rich repeat
    cl15307
    Location:656705
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  3. NM_004787.4NP_004778.1  slit homolog 2 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_004778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA489463, AC021118, AC096718, AK126459, BC117190, BF112143, BI494498, BM474839, CV370469, DA721496, DB207352
    Consensus CDS
    CCDS3426.1
    UniProtKB/Swiss-Prot
    O94813
    Related
    ENSP00000422591.1, ENST00000504154.5
    Conserved Domains (10) summary
    smart00013
    Location:2758
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:859908
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:11831316
    LamG; Laminin G domain
    cd00054
    Location:10761112
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:851863
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3856
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:324364
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:777837
    LRR_8; Leucine rich repeat
    cl15307
    Location:664713
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    20251905..20620561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248211.3XP_005248268.1  slit homolog 2 protein isoform X1

    Related
    ENSP00000273739.5, ENST00000273739.9
    Conserved Domains (10) summary
    smart00013
    Location:2758
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:863912
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:11871320
    LamG; Laminin G domain
    cd00054
    Location:10801116
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:855867
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3856
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:328368
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:781841
    LRR_8; Leucine rich repeat
    cl15307
    Location:668717
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. XM_006713986.3XP_006714049.1  slit homolog 2 protein isoform X2

    Conserved Domains (9) summary
    smart00013
    Location:2758
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:839888
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:11631296
    LamG; Laminin G domain
    cd00054
    Location:10561092
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:43214
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:3856
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:328368
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:55115
    LRR_8; Leucine rich repeat
    cl15307
    Location:668717
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  3. XM_011513909.2XP_011512211.1  slit homolog 2 protein isoform X3

    Conserved Domains (10) summary
    smart00013
    Location:697728
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:829878
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:11531286
    LamG; Laminin G domain
    cd00054
    Location:10461082
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:47180
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:821833
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:2746
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:294334
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:747807
    LRR_8; Leucine rich repeat
    cl15307
    Location:634683
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  4. XM_017008845.1XP_016864334.1  slit homolog 2 protein isoform X4

    Related
    ENSP00000482129.1, ENST00000622093.4
  5. XM_011513910.2XP_011512212.2  slit homolog 2 protein isoform X5

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