SLIT2 slit guidance ligand 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLIT2provided by HGNC
Official Full Name: slit guidance ligand 2provided by HGNC
Primary source: HGNC:HGNC:11086
See related: Ensembl:ENSG00000145147 MIM:603746
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SLIL3; Slit-2
Summary: This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Broad expression in lung (RPKM 13.1), adrenal (RPKM 9.9) and 21 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 4p15.31

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	4	NC_000004.12 (20251905..20620561)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (20254566..20622184)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

an interaction between the BMP2-Gremlin and SLIT2 pathways in human kidney cells
Title: Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways.
SLIT2/ROBO1 signalling may regulate trophoblast differentiation and invasion causing restricting beta human chorionic gonadotrophin (beta-hCG) production, shallow trophoblast invasion and inhibiting placental angiogenesis in missed and threatened miscarriage during the first trimester.
Title: Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy.
The findings indicate that the migration of human neural progenitor cells from the fetal subventricular zone to the olfactory bulb is partially regulated by the Slit2-Robo1 axis.
Title: Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells During Development.
Elevated SLIT2 promoter methylation contributed to the risk of NPC.
Title: Promoter hypermethylation of SLIT2 is a risk factor and potential diagnostic biomarker for nasopharyngeal carcinoma.
Curcumin up-regulates Slit-2 and down-regulates the expression of CXCR4, SDF-1, MMP2 and MMP9 in Ishikawa, Hec- 1B and primary human endometrial carcinoma cells.
Title: Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells.
The alteration of Slit2 and Robo1 expression in the retinas of diabetic rats and patients with proliferative diabetic retinopathy suggests a role for the Slit-Robo signal in the various stages diabetic retinopathy.
Title: The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy.
human placental multipotent mesenchymal stromal cell express Slit2 and both Robo1 and Robo4 are present in human umbilical vein endothelial cells.
Title: Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling.
Slit2-Robo1 signaling promoted the adhesion, invasion and migration of tongue carcinoma cells by upregulating the expression levels of MMP2 and MMP9 and, downregulating the expression of E-cadherin.
Title: Slit2‑Robo1 signaling promotes the adhesion, invasion and migration of tongue carcinoma cells via upregulating matrix metalloproteinases 2 and 9, and downregulating E‑cadherin.
findings suggest that AK3 and SLIT2 may be potential candidates involved in genetic susceptibility to colorectal cancer
Title: Candidate predisposing germline copy number variants in early onset colorectal cancer patients.
Low Slit2 expression is associated with glioma.
Title: Slit2 and Robo1 expression as biomarkers for assessing prognosis in brain glioma patients.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
HIV-1 dendritic cell-to-T cell transmission is inhibited by the presence of recombinant, extracellular Slit2N	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced ROBO1-actin association	PubMed
	env	The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced actin polymerization in T cells	PubMed
	env	The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced phosphorylation of both LIMK1 and cofilin	PubMed
	env	SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells	PubMed
	env	Inhibition of M-tropic HIV-1 gp120-induced transendothelial migration by SLIT2N involves SLIT2N-mediated enhancement of co-localization of Robo1 with WASp and LSP1 in immature monocyte-derived dendritic cells	PubMed
	env	SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced association of LSP1, Wiskott-Aldrich Syndrome protein (WASp), Actin-Related Protein 2/3 (Arp2/3), and beta-actin in immature monocyte-derived dendritic cells	PubMed
	env	SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induces transendothelial migration and podosome formation in immature monocyte-derived dendritic cells	PubMed
	env	SLIT2 inhibits HIV-1-induced lymphatic hyperpermeability by blocking the interaction between Robo4 and integrin alpha5beta1 in human lymphatic endothelial cells	PubMed
	env	SLIT2 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells	PubMed
	env	HIV-1 gp120 modulates the expression of SLIT2 in human lymphatic endothelial cells	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of slit homolog 2 (SLIT2) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Go to the top of the page Help

Activation of Rac, organism-specific biosystem (from REACTOME)
Activation of Rac, organism-specific biosystemA low level of Rac activity is essential to maintain axon outgrowth and Robo activation recruits Sos, a dual specificity GEF to the plasma membrane via Dock to activate Rac during midline repulsion.
Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
Glypican 1 network, organism-specific biosystem
Glypican 1 network
Inactivation of Cdc42 and Rac, organism-specific biosystem (from REACTOME)
Inactivation of Cdc42 and Rac, organism-specific biosystemRho family GTPases including Rac, Rho, and Cdc42 are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed...
Netrin-1 signaling, organism-specific biosystem (from REACTOME)
Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystem (from REACTOME)
Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystemCommissural axons project to the floor plate, attracted by the interaction of their DCC receptors with netrin1 produced by floor plate cells. The axons are insensitive to the repulsive action of slit...
Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
Role of Abl in Robo-Slit signaling, organism-specific biosystemAbl plays a dual role in the Robo pathway. As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed ba...
Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D4S2742 (e-PCR)
- UniSTS:55577

G34229 (e-PCR)
- UniSTS:1309

SHGC-50557 (e-PCR)
- UniSTS:1319

D4S331 (e-PCR)
- UniSTS:88359

D4S2611 (e-PCR)
- UniSTS:73259

SHGC-50605 (e-PCR)
- UniSTS:304

D4S279 (e-PCR)
- UniSTS:47706

SHGC-149436 (e-PCR)
- UniSTS:177005

SLIT2 (e-PCR)
- UniSTS:479854

G34103 (e-PCR)
- UniSTS:77945

SHGC-67708 (e-PCR)
- UniSTS:4235

D4S1372 (e-PCR)
- UniSTS:46222

SHGC-51362 (e-PCR)
- UniSTS:80293

STS-R78732 (e-PCR)
- UniSTS:32465

D4S1063 (e-PCR)
- UniSTS:24278

RH102649 (e-PCR)
- UniSTS:96983

D4S3124 (e-PCR)
- UniSTS:5097

SHGC-50719 (e-PCR)
- UniSTS:5098

SHGC-24805 (e-PCR)
- UniSTS:58347

D4S544 (e-PCR)
- UniSTS:75245

SHGC-149242 (e-PCR)
- UniSTS:176882

Homology

Homologs of the SLIT2 gene: The SLIT2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 245 organisms have orthologs with human gene SLIT2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
GTPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
Roundabout binding	IPI Inferred from Physical Interaction more info	PubMed
calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
heparin binding	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
laminin-1 binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
proteoglycan binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Roundabout signaling pathway	IC Inferred by Curator more info	PubMed
Roundabout signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
apoptotic process involved in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
axon guidance	IDA Inferred from Direct Assay more info	PubMed
axon guidance	TAS Traceable Author Statement more info
branching morphogenesis of an epithelial tube	IDA Inferred from Direct Assay more info	PubMed
branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to heparin	IDA Inferred from Direct Assay more info	PubMed
cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
NOT chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	IDA Inferred from Direct Assay more info	PubMed
chemorepulsion involved in postnatal olfactory bulb interneuron migration	IDA Inferred from Direct Assay more info	PubMed
corticospinal neuron axon guidance through spinal cord	IMP Inferred from Mutant Phenotype more info	PubMed
induction of negative chemotaxis	IDA Inferred from Direct Assay more info	PubMed
motor neuron axon guidance	IDA Inferred from Direct Assay more info	PubMed
negative chemotaxis	IDA Inferred from Direct Assay more info	PubMed
negative chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
negative regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
negative regulation of chemokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed
negative regulation of leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of mononuclear cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of retinal ganglion cell axon guidance	IDA Inferred from Direct Assay more info	PubMed
negative regulation of small GTPase mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of vascular permeability	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of axonogenesis	TAS Traceable Author Statement more info	PubMed
pulmonary valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
response to cortisol	IEP Inferred from Expression Pattern more info	PubMed
retinal ganglion cell axon guidance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
retinal ganglion cell axon guidance	IDA Inferred from Direct Assay more info	PubMed
ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
ventricular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
extracellular exosome	HDA more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
membrane	NAS Non-traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: slit homolog 2 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047105.1 RefSeqGene

Range

4981..373637

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001289135.2 → NP_001276064.1 slit homolog 2 protein isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains one alternate in-frame exon and lacks one alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AA489463, AC021118, AC096718, AF133270, AK126459, BC143978, BF112143, BI494498, BM474839, CV370469, DA721496, DB207352

Consensus CDS

CCDS75110.1

UniProtKB/Swiss-Prot

O94813

Related

ENSP00000422261.1, ENST00000503837.5

Conserved Domains (10) summary

smart00013
Location:27 → 58

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:855 → 904

LRRCT; Leucine rich repeat C-terminal domain

smart00282
Location:1179 → 1312

LamG; Laminin G domain

cd00054
Location:1072 → 1108

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00116
Location:43 → 214

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:847 → 859

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:38 → 56

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:328 → 368

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:773 → 833

LRR_8; Leucine rich repeat

cl15307
Location:660 → 709

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001289136.2 → NP_001276065.1 slit homolog 2 protein isoform 3 precursor

See identical proteins and their annotated locations for NP_001276065.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AA489463, AC021118, AC096718, AK126459, BC143978, BF112143, BI494498, BM474839, CV370469, DA721496, DB207352

Consensus CDS

CCDS75111.1

UniProtKB/Swiss-Prot

O94813

Related

ENSP00000427548.1, ENST00000503823.5

Conserved Domains (10) summary

smart00013
Location:27 → 58

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:851 → 900

LRRCT; Leucine rich repeat C-terminal domain

smart00282
Location:1175 → 1308

LamG; Laminin G domain

cd00054
Location:1068 → 1104

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00116
Location:43 → 214

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:843 → 855

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:38 → 56

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:324 → 364

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:769 → 829

LRR_8; Leucine rich repeat

cl15307
Location:656 → 705

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_004787.4 → NP_004778.1 slit homolog 2 protein isoform 1 precursor

See identical proteins and their annotated locations for NP_004778.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA489463, AC021118, AC096718, AK126459, BC117190, BF112143, BI494498, BM474839, CV370469, DA721496, DB207352

Consensus CDS

CCDS3426.1

UniProtKB/Swiss-Prot

O94813

Related

ENSP00000422591.1, ENST00000504154.5

Conserved Domains (10) summary

smart00013
Location:27 → 58

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:859 → 908

LRRCT; Leucine rich repeat C-terminal domain

smart00282
Location:1183 → 1316

LamG; Laminin G domain

cd00054
Location:1076 → 1112

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00116
Location:43 → 214

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:851 → 863

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:38 → 56

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:324 → 364

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:777 → 837

LRR_8; Leucine rich repeat

cl15307
Location:664 → 713

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p12 Primary Assembly

Range

20251905..20620561

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005248211.3 → XP_005248268.1 slit homolog 2 protein isoform X1

Related

ENSP00000273739.5, ENST00000273739.9

Conserved Domains (10) summary

smart00013
Location:27 → 58

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:863 → 912

LRRCT; Leucine rich repeat C-terminal domain

smart00282
Location:1187 → 1320

LamG; Laminin G domain

cd00054
Location:1080 → 1116

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00116
Location:43 → 214

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:855 → 867

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:38 → 56

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:328 → 368

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:781 → 841

LRR_8; Leucine rich repeat

cl15307
Location:668 → 717

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006713986.3 → XP_006714049.1 slit homolog 2 protein isoform X2

Conserved Domains (9) summary

smart00013
Location:27 → 58

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:839 → 888

LRRCT; Leucine rich repeat C-terminal domain

smart00282
Location:1163 → 1296

LamG; Laminin G domain

cd00054
Location:1056 → 1092

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00116
Location:43 → 214

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:38 → 56

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:328 → 368

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:55 → 115

LRR_8; Leucine rich repeat

cl15307
Location:668 → 717

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_011513909.2 → XP_011512211.1 slit homolog 2 protein isoform X3

Conserved Domains (10) summary

smart00013
Location:697 → 728

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:829 → 878

LRRCT; Leucine rich repeat C-terminal domain

smart00282
Location:1153 → 1286

LamG; Laminin G domain

cd00054
Location:1046 → 1082

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00116
Location:47 → 180

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:821 → 833

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:27 → 46

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:294 → 334

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:747 → 807

LRR_8; Leucine rich repeat

cl15307
Location:634 → 683

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_017008845.1 → XP_016864334.1 slit homolog 2 protein isoform X4

Related

ENSP00000482129.1, ENST00000622093.4
XM_011513910.2 → XP_011512212.2 slit homolog 2 protein isoform X5