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    AZGP1 alpha-2-glycoprotein 1, zinc-binding [ Homo sapiens (human) ]

    Gene ID: 563, updated on 7-Apr-2024

    Summary

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    Official Symbol
    AZGP1provided by HGNC
    Official Full Name
    alpha-2-glycoprotein 1, zinc-bindingprovided by HGNC
    Primary source
    HGNC:HGNC:910
    See related
    Ensembl:ENSG00000160862 MIM:194460; AllianceGenome:HGNC:910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAG; ZA2G
    Summary
    Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in salivary gland (RPKM 748.1), liver (RPKM 688.6) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99966730..99976031, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101206237..101220128, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99564353..99573654, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99526456-99527041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99527042-99527626 Neighboring gene gap junction protein gamma 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99541581-99542436 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99543294-99544149 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99580686-99580841 Neighboring gene AZGP1 pseudogene 1 Neighboring gene gap junction protein gamma 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients. Chan GC, et al. Sci Rep, 2022 May 31. PMID 35641588, Free PMC Article
    2. Development of a prediction model for mortality and cardiovascular outcomes in older adults taking into account AZGP1. Huscher D, et al. Sci Rep, 2021 Jun 3. PMID 34083628, Free PMC Article
    3. Changes of Serum Zinc-α2-Glycoprotein Level and Analysis of Its Related Factors in Gestational Diabetes Mellitus. Xu D, et al. J Diabetes Res, 2021. PMID 33681385, Free PMC Article
    4. Zinc-α2-glycoprotein is associated with non-albuminuric chronic kidney disease progression in type 2 diabetes: a retrospective study with 4-year follow-up. Moh A, et al. Diabet Med, 2020 Nov. PMID 32353891
    5. Low Serum ZAG Levels Correlate With Determinants of the Metabolic Syndrome in Chinese Subjects. Wang L, et al. Front Endocrinol (Lausanne), 2020. PMID 32265843, Free PMC Article

    See all (183) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics.
      Title: Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics.
    2. Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.
      Title: Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.
    3. Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
      Title: Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.
    4. CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway.
      Title: CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway.
    5. Effects of Weight Loss and Aerobic Exercise Training on Adi-Pose Tissue Zinc alpha2-Glycoprotein and Associated Genes in Obesity.
      Title: Effects of Weight Loss and Aerobic Exercise Training on Adi-Pose Tissue Zinc α2-Glycoprotein and Associated Genes in Obesity.
    6. Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.
      Title: Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.
    7. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4(+) T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy.
      Title: Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4(+) T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy.
    8. Effect of a single bout of resistance exercise on zinc-alpha2-glycoprotein.
      Title: Effect of a single bout of resistance exercise on zinc-α2-glycoprotein.
    9. Assessment of Zinc- alpha2 glycoprotein (ZAG) and Lipase Maturation Factor 1 (LMF1) concentration in children with chronic kidney disease.
      Title: Assessment of Zinc- alpha2 glycoprotein (ZAG) and Lipase Maturation Factor 1 (LMF1) concentration in children with chronic kidney disease.
    10. Development of a prediction model for mortality and cardiovascular outcomes in older adults taking into account AZGP1.
      Title: Development of a prediction model for mortality and cardiovascular outcomes in older adults taking into account AZGP1.
    Submit: New GeneRIF Correction See all GeneRIFs (102)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA nuclease activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    zinc-alpha-2-glycoprotein
    Names
    Alpha-2-glycoprotein, zinc
    Zn-alpha2-glycoprotein
    testicular tissue protein Li 227
    zn-alpha-2-GP
    zn-alpha-2-glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185.4 → NP_001176.1  zinc-alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_001176.1

      Status: VALIDATED

      Source sequence(s)
      BC005306, BC033830
      Consensus CDS
      CCDS5680.1
      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00
      Related
      ENSP00000292401.4, ENST00000292401.9
      Conserved Domains (2) summary
      cd07698
      Location:205 → 296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 → 201
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      99966730..99976031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101206237..101220128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358658.1 → XP_054214633.1  zinc-alpha-2-glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00

    2. XM_054358657.1 → XP_054214632.1  zinc-alpha-2-glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25311.2 GenPept UniProtKB/Swiss-Prot:P25311

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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