Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camk2n2provided by RGD
Official Full Name: calcium/calmodulin-dependent protein kinase II inhibitor 2provided by RGD
Primary source: RGD:708411
See related: AllianceGenome:RGD:708411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Predicted to be involved in negative regulation of protein kinase activity. Predicted to be located in centrosome and nucleoplasm. Orthologous to human CAMK2N2 (calcium/calmodulin dependent protein kinase II inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 90.4), Testes (RPKM 18.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (93792112..93796153)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (80289702..80290829)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (83975430..83976557)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-fat diet-induced mitochondrial biogenesis is regulated by mitochondrial-derived reactive oxygen species activation of CaMKII
Title: High-fat diet-induced mitochondrial biogenesis is regulated by mitochondrial-derived reactive oxygen species activation of CaMKII.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:485633 (e-PCR)
- UniSTS:485633

UniSTS:480474 (e-PCR)
- UniSTS:480474

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic plasticity	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase II inhibitor 2

Names: CaM-KII inhibitory protein; caM-KIIN; caM-KIINbeta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021678.1 → NP_067710.1 calcium/calmodulin-dependent protein kinase II inhibitor 2

See identical proteins and their annotated locations for NP_067710.1

Status: PROVISIONAL

Source sequence(s)

AF041854

UniProtKB/Swiss-Prot

Q9Z2N6

Conserved Domains (1) summary

pfam15170
Location:1 → 79

CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor