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CAMK2N2 calcium/calmodulin dependent protein kinase II inhibitor 2 [ Homo sapiens (human) ]

Gene ID: 94032, updated on 4-Dec-2022

Summary

Official Symbol
CAMK2N2provided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II inhibitor 2provided by HGNC
Primary source
HGNC:HGNC:24197
See related
Ensembl:ENSG00000163888 MIM:608721; AllianceGenome:HGNC:24197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKIIN; CAM-KIIN
Summary
This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 13.3), adrenal (RPKM 4.9) and 1 other tissue See more
Orthologs
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Genomic context

See CAMK2N2 in Genome Data Viewer
Location:
3q27.1
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (184259213..184261553, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (187068515..187070855, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183977001..183979341, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene EEF1AKMT4-ECE2 readthrough Neighboring gene ALG3 alpha-1,3- mannosyltransferase Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene endothelin converting enzyme 2 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase II inhibitor 2
Names
CaM-KII inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033259.3NP_150284.1  calcium/calmodulin-dependent protein kinase II inhibitor 2

    See identical proteins and their annotated locations for NP_150284.1

    Status: REVIEWED

    Source sequence(s)
    AC061705, AC078797, AY037149
    Consensus CDS
    CCDS3257.1
    UniProtKB/Swiss-Prot
    Q96S95
    Related
    ENSP00000296238.3, ENST00000296238.4
    Conserved Domains (1) summary
    pfam15170
    Location:179
    CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    184259213..184261553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    187068515..187070855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)