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    CRH corticotropin releasing hormone [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 702877, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CRHprovided by VGNC
    Official Full Name
    corticotropin releasing hormoneprovided by VGNC
    Primary source
    VGNC:VGNC:71490
    See related
    Ensembl:ENSMMUG00000021587
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (66821292..66823589, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (64314498..64316818, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114680268 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene tripartite motif containing 55 Neighboring gene uncharacterized LOC114680269 Neighboring gene ribosome biogenesis regulator 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit. Kalin NH, et al. Biol Psychiatry, 2016 Sep 1. PMID 27016385, Free PMC Article
    2. Functional CRH variation increases stress-induced alcohol consumption in primates. Barr CS, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706546, Free PMC Article
    3. CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Barr CS, et al. Arch Gen Psychiatry, 2008 Aug. PMID 18678798, Free PMC Article
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results of this study indicated that chronic CRF overexpression in primates not only increases Anxious Temperament but also affects metabolism and connectivity within components of Anxious Temperament 's neural circuitry.
      Title: Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit.
    2. Data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals.
      Title: Functional CRH variation increases stress-induced alcohol consumption in primates.
    3. We show that -2232C>G alters DNA x protein interactions and confers decreased sensitivity of the CRH promoter to glucocorticoids in vitro.
      Title: CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables corticotropin-releasing hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of glucagon secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cortisol secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    corticoliberin
    Names
    corticoliberin preproprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      66821292..66823589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001094433.4 → XP_001094433.1  corticoliberin

      See identical proteins and their annotated locations for XP_001094433.1

      UniProtKB/TrEMBL
      F7E8Q2, G8F161
      Related
      ENSMMUP00000028431.2, ENSMMUT00000030381.4
      Conserved Domains (1) summary
      pfam00473
      Location:157 → 194
      CRF; Corticotropin-releasing factor family
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials