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    PAXIP1-DT PAXIP1 divergent transcript [ Homo sapiens (human) ]

    Gene ID: 202781, updated on 25-Dec-2023

    Summary

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    Official Symbol
    PAXIP1-DTprovided by HGNC
    Official Full Name
    PAXIP1 divergent transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:27328
    See related
    Ensembl:ENSG00000273344 AllianceGenome:HGNC:27328
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAXIP1-AS1
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    Genomic context

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    Location:
    7q36.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (155003433..155005703)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (156178707..156180978)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (154795143..154797413)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26889 Neighboring gene PAXIP1 antisense RNA 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:154737734-154738933 Neighboring gene PAX interacting protein 1 Neighboring gene uncharacterized LOC124901781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154795729-154796230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:154862583-154863409 Neighboring gene HTR5A antisense RNA 1 Neighboring gene 5-hydroxytryptamine receptor 5A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:154914484-154915093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959387-154959888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959889-154960388 Neighboring gene uncharacterized LOC105375584

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation. Li J, et al. Cell Death Dis, 2023 May 24. PMID 37225681, Free PMC Article
    2. H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis. Ma Y, et al. J Ovarian Res, 2021 Jun 9. PMID 34108034, Free PMC Article
    3. LncRNA PAXIP1-AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis. Song R, et al. J Cell Mol Med, 2021 Aug. PMID 34245091, Free PMC Article
    4. Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression. Xu H, et al. J Exp Clin Cancer Res, 2019 Dec 10. PMID 31823805, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer.
      Title: PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer.
    2. The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation.
      Title: The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation.
    3. LncRNA PAXIP1-AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis.
      Title: LncRNA PAXIP1-AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis.
    4. LncRNA PAXIP1-AS1 was highly expressed in glioma and associated with poor prognosis. Highly expressed lncRNA PAXIP1-AS1 promoted glioma cell migration, invasion and angiogenesis by recruiting transcription factor ETS1 to upregulate KIF14 expression. However, its silencing inhibited migration, invasion and angiogenesis of glioma cells.
      Title: Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • PAXIP1 antisense RNA 1 (head to head)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028090.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093726, AI075258, AL713756, BI438440
      Related
      ENST00000608317.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      155003433..155005703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      156178707..156180978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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