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    FUT4 fucosyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 2526, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FUT4provided by HGNC
    Official Full Name
    fucosyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:4015
    See related
    Ensembl:ENSG00000196371 MIM:104230; AllianceGenome:HGNC:4015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV
    Summary
    The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
    Orthologs
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    Genomic context

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    Location:
    11q21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (94543921..94549895)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (94550967..94556942)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94277087..94283061)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94245285-94245803 Neighboring gene ankyrin repeat domain 49 Neighboring gene chromosome 11 open reading frame 97 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94278664-94279338 Neighboring gene PIWIL4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94300071-94300572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94300573-94301072 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:94317056-94318255 Neighboring gene piwi like RNA-mediated gene silencing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5405 Neighboring gene MPRA-validated peak1402 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94373181-94373680 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94379786-94380519 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:94382939-94383514 Neighboring gene long intergenic non-protein coding RNA 2700 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:94389595-94390531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CD15 immunostaining improves placental diagnosis of fetal hypoxia. Seidmann L, et al. Placenta, 2021 Feb. PMID 33545630
    2. Specific Norovirus Interaction with Lewis x and Lewis a on Human Intestinal Inflammatory Mucosa during Refractory Inflammatory Bowel Disease. Tarris G, et al. mSphere, 2021 Jan 13. PMID 33441404, Free PMC Article
    3. Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma. Lu HH, et al. EBioMedicine, 2020 Jul. PMID 32629386, Free PMC Article
    4. Expression of the cancer stem cell marker SSEA1 is associated with poor survival in metastatic high-grade serous carcinoma. Davidson B, et al. Virchows Arch, 2020 Nov. PMID 32472195, Free PMC Article
    5. Role of fucosyltransferase IV in the migration and invasion of human melanoma cells. Shan X, et al. IUBMB Life, 2020 May. PMID 31961483

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility.
      Title: ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility.
    2. X-ray inhibits FUT4-mediated proliferation in A549 cells by downregulating SP1 expression.
      Title: X-ray inhibits FUT4-mediated proliferation in A549 cells by downregulating SP1 expression.
    3. SMYD2 facilitates cancer cell malignancy and xenograft tumor development through ERBB2-mediated FUT4 expression in colon cancer.
      Title: SMYD2 facilitates cancer cell malignancy and xenograft tumor development through ERBB2-mediated FUT4 expression in colon cancer.
    4. CD15(+) Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Colorectal Cancer Cells.
      Title: CD15(+) Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Colorectal Cancer Cells.
    5. CD15 immunostaining improves placental diagnosis of fetal hypoxia.
      Title: CD15 immunostaining improves placental diagnosis of fetal hypoxia.
    6. MyoD1 suppresses cell migration and invasion by inhibiting FUT4 transcription in human gastric cancer cells.
      Title: MyoD1 suppresses cell migration and invasion by inhibiting FUT4 transcription in human gastric cancer cells.
    7. Specific Norovirus Interaction with Lewis x and Lewis a on Human Intestinal Inflammatory Mucosa during Refractory Inflammatory Bowel Disease.
      Title: Specific Norovirus Interaction with Lewis x and Lewis a on Human Intestinal Inflammatory Mucosa during Refractory Inflammatory Bowel Disease.
    8. Role of fucosyltransferase IV in the migration and invasion of human melanoma cells.
      Title: Role of fucosyltransferase IV in the migration and invasion of human melanoma cells.
    9. Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
      Title: Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
    10. Long noncoding RNA GAS6-AS2 sponges microRNA-493, thereby enhancing the malignant characteristics of breast cancer cells via upregulation of FUT4.
      Title: Long noncoding RNA GAS6-AS2 sponges microRNA-493, thereby enhancing the malignant characteristics of breast cancer cells via upregulation of FUT4.
    Submit: New GeneRIF Correction See all GeneRIFs (85)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-fucose catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lymphocyte migration into lymph node ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in oligosaccharide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of leukocyte tethering or rolling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neutrophil migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-(1,3)-fucosyltransferase 4
    Names
    4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
    ELAM ligand fucosyltransferase
    ELAM-1 ligand fucosyltransferase
    Lewis X
    alpha (1,3) fucosyltransferase, myeloid-specific
    fucT-IV
    fucosyltransferase IV
    galactoside 3-L-fucosyltransferase
    stage-specific embryonic antigen 1
    NP_002024.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002033.4 → NP_002024.1  alpha-(1,3)-fucosyltransferase 4

      See identical proteins and their annotated locations for NP_002024.1

      Status: REVIEWED

      Source sequence(s)
      AP000943
      Consensus CDS
      CCDS8301.1
      UniProtKB/Swiss-Prot
      B2RMS0, P22083
      Related
      ENSP00000351602.2, ENST00000358752.4
      Conserved Domains (2) summary
      pfam00852
      Location:353 → 525
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:186 → 331
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      94543921..94549895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      94550967..94556942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22083.3 GenPept UniProtKB/Swiss-Prot:P22083

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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