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    Sugp1 SURP and G patch domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70616, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sugp1provided by MGI
    Official Full Name
    SURP and G patch domain containing 1provided by MGI
    Primary source
    MGI:MGI:1917866
    See related
    Ensembl:ENSMUSG00000011306 AllianceGenome:MGI:1917866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sf4; 5730496N02Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human SUGP1 (SURP and G-patch domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.9), CNS E14 (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70495435..70524997)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70042769..70072347)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21762 Neighboring gene nucleoside diphosphate kinase B pseudogene Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene STARR-positive B cell enhancer ABC_E9314 Neighboring gene transmembrane 6 superfamily member 2 Neighboring gene hyaluronan and proteoglycan link protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SUGP1 is a novel regulator of cholesterol metabolism. Kim MJ, et al. Hum Mol Genet, 2016 Jul 15. PMID 27206982, Free PMC Article
    2. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson ND, et al. Gene, 2003 Feb 13. PMID 12594045
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SURP and G-patch domain-containing protein 1
    Names
    splicing factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368391.1 → NP_001355320.1  SURP and G-patch domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AC167132
      Consensus CDS
      CCDS22356.1
      UniProtKB/Swiss-Prot
      Q0VAT9, Q3U0W3, Q8CH02, Q8R094

    2. NM_027481.3 → NP_081757.1  SURP and G-patch domain-containing protein 1

      See identical proteins and their annotated locations for NP_081757.1

      Status: VALIDATED

      Source sequence(s)
      AC167132
      Consensus CDS
      CCDS22356.1
      UniProtKB/Swiss-Prot
      Q0VAT9, Q3U0W3, Q8CH02, Q8R094
      Related
      ENSMUSP00000011450.7, ENSMUST00000011450.8
      Conserved Domains (2) summary
      pfam01585
      Location:561 → 605
      G-patch; G-patch domain
      pfam01805
      Location:186 → 237
      Surp; Surp module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70495435..70524997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243755.2 → XP_030099615.1  SURP and G-patch domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      PRK12270
      Location:335 → 458
      kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
      pfam01585
      Location:603 → 645
      G-patch; G-patch domain
      pfam01805
      Location:227 → 278
      Surp; Surp module

    2. XM_036154283.1 → XP_036010176.1  SURP and G-patch domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      PRK12270
      Location:87 → 210
      kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
      pfam01585
      Location:355 → 399
      G-patch; G-patch domain
      pfam01805
      Location:55 → 106
      Surp; Surp module
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CH02.1 GenPept UniProtKB/Swiss-Prot:Q8CH02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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