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SUGP1 SURP and G-patch domain containing 1 [ Homo sapiens (human) ]

Gene ID: 57794, updated on 1-Jun-2020

Summary

Official Symbol
SUGP1provided by HGNC
Official Full Name
SURP and G-patch domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18643
See related
Ensembl:ENSG00000105705 MIM:607992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP; SF4; F23858
Summary
SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]
Expression
Ubiquitous expression in testis (RPKM 17.9), spleen (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See SUGP1 in Genome Data Viewer
Location:
19p13.11
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (19276033..19320509, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19387320..19431321, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 4 Neighboring gene transmembrane 6 superfamily member 2 Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene GATA zinc finger domain containing 2A Neighboring gene microRNA 640

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
NHGRI GWA Catalog
Genome-wide analysis of hepatic lipid content in extreme obesity.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434E2216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SURP and G-patch domain-containing protein 1
Names
RNA-binding protein RBP
splicing factor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172231.4NP_757386.2  SURP and G-patch domain-containing protein 1

    See identical proteins and their annotated locations for NP_757386.2

    Status: VALIDATED

    Source sequence(s)
    AC003967, AY072917, DC363162
    Consensus CDS
    CCDS12399.1
    UniProtKB/Swiss-Prot
    Q8IWZ8
    Related
    ENSP00000247001.3, ENST00000247001.10
    Conserved Domains (3) summary
    smart00648
    Location:264318
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam01585
    Location:563607
    G-patch; G-patch domain
    pfam01805
    Location:190241
    Surp; Surp module

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    19276033..19320509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528155.2XP_011526457.1  SURP and G-patch domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011526457.1

    UniProtKB/TrEMBL
    A0A024R7N3
    Conserved Domains (3) summary
    pfam01585
    Location:353397
    G-patch; G-patch domain
    pfam01805
    Location:55106
    Surp; Surp module
    cl27863
    Location:40151
    SSL_OB; Staphylococcal superantigen-like OB-fold domain
  2. XM_024451628.1XP_024307396.1  SURP and G-patch domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    pfam01585
    Location:353397
    G-patch; G-patch domain
    pfam01805
    Location:55106
    Surp; Surp module
    cl27863
    Location:40151
    SSL_OB; Staphylococcal superantigen-like OB-fold domain
  3. XM_024451627.1XP_024307395.1  SURP and G-patch domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    pfam01585
    Location:386430
    G-patch; G-patch domain
    pfam01805
    Location:88139
    Surp; Surp module
    cl27863
    Location:73184
    SSL_OB; Staphylococcal superantigen-like OB-fold domain
  4. XM_005260002.3XP_005260059.1  SURP and G-patch domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005260059.1

    UniProtKB/TrEMBL
    A0A024R7N3
    Conserved Domains (3) summary
    pfam01585
    Location:353397
    G-patch; G-patch domain
    pfam01805
    Location:55106
    Surp; Surp module
    cl27863
    Location:40151
    SSL_OB; Staphylococcal superantigen-like OB-fold domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021164.2: Suppressed sequence

    Description
    NM_021164.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_182812.1: Suppressed sequence

    Description
    NM_182812.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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