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    RICTOR RPTOR independent companion of MTOR complex 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 479356, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RICTORprovided by VGNC
    Official Full Name
    RPTOR independent companion of MTOR complex 2provided by VGNC
    Primary source
    VGNC:VGNC:45574
    See related
    Ensembl:ENSCAFG00845003291
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See RICTOR in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (70411989..70529395)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (69572398..69689560)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (70812437..70929811)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (70160959..70278302)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (70273578..70390878)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene complement C9 Neighboring gene uncharacterized LOC119871559 Neighboring gene FYN binding protein 1 Neighboring gene uncharacterized LOC119871560 Neighboring gene 60S ribosomal protein L37a-like Neighboring gene 60S ribosomal protein L23a-like Neighboring gene uncharacterized LOC111095627 Neighboring gene oncostatin M receptor Neighboring gene uncharacterized LOC106558692

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC2 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rapamycin-insensitive companion of mTOR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      70411989..70529395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038663863.1 → XP_038519791.1  rapamycin-insensitive companion of mTOR isoform X1

      UniProtKB/TrEMBL
      A0A8C0M577, A0A8C0STP4, A0A8I3RR99
      Related
      ENSCAFP00845004633.1, ENSCAFT00845005834.1
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. XM_038663864.1 → XP_038519792.1  rapamycin-insensitive companion of mTOR isoform X2

      UniProtKB/TrEMBL
      A0A8C0M1J1, A0A8I3MHW6, A0A8P0P8D2
      Related
      ENSCAFP00845004769.1, ENSCAFT00845005999.1
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. XM_038663865.1 → XP_038519793.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      A0A8C0STP4
      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    4. XM_038663866.1 → XP_038519794.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      A0A8C0STP4
      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      70160959..70278302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038474140.1 → XP_038330068.1  rapamycin-insensitive companion of mTOR isoform X1

      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. XM_038474141.1 → XP_038330069.1  rapamycin-insensitive companion of mTOR isoform X2

      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. XM_038474142.1 → XP_038330070.1  rapamycin-insensitive companion of mTOR isoform X3

      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    4. XM_038474143.1 → XP_038330071.1  rapamycin-insensitive companion of mTOR isoform X3

      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      70273578..70390878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038599530.1 → XP_038455458.1  rapamycin-insensitive companion of mTOR isoform X1

      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. XM_038599531.1 → XP_038455459.1  rapamycin-insensitive companion of mTOR isoform X2

      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. XM_038599532.1 → XP_038455460.1  rapamycin-insensitive companion of mTOR isoform X3

      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    4. XM_038599533.1 → XP_038455461.1  rapamycin-insensitive companion of mTOR isoform X3

      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      70812437..70929811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038535257.1 → XP_038391185.1  rapamycin-insensitive companion of mTOR isoform X1

      UniProtKB/TrEMBL
      A0A8C0M577, A0A8C0STP4, A0A8I3RR99
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. XM_038535258.1 → XP_038391186.1  rapamycin-insensitive companion of mTOR isoform X2

      UniProtKB/TrEMBL
      A0A8C0M1J1, A0A8I3MHW6, A0A8P0P8D2
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. XM_038535259.1 → XP_038391187.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      A0A8C0STP4
      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    4. XM_038535260.1 → XP_038391188.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      A0A8C0STP4
      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      69572398..69689560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038499516.1 → XP_038355444.1  rapamycin-insensitive companion of mTOR isoform X1

      UniProtKB/TrEMBL
      A0A8C0M577, A0A8C0STP4, A0A8I3RR99
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. XM_038499526.1 → XP_038355454.1  rapamycin-insensitive companion of mTOR isoform X2

      UniProtKB/TrEMBL
      A0A8C0M1J1, A0A8I3MHW6, A0A8P0P8D2
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. XM_014113125.3 → XP_013968600.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      A0A8C0STP4
      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    4. XM_014113127.3 → XP_013968602.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      A0A8C0STP4
      Conserved Domains (5) summary
      pfam14663
      Location:694 → 800
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:5 → 384
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1032 → 1135
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:584 → 687
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:869 → 938
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    Nucleotide Protein
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