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Rictor RPTOR independent companion of MTOR, complex 2 [ Mus musculus (house mouse) ]

Gene ID: 78757, updated on 19-Sep-2021

Summary

Official Symbol
Rictorprovided by MGI
Official Full Name
RPTOR independent companion of MTOR, complex 2provided by MGI
Primary source
MGI:MGI:1926007
See related
Ensembl:ENSMUSG00000050310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AVO3; AW492497; 4921505C17Rik; 6030405M08Rik; D530039E11Rik
Expression
Ubiquitous expression in thymus adult (RPKM 3.9), cerebellum adult (RPKM 2.3) and 28 other tissues See more
Orthologs
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Genomic context

See Rictor in Genome Data Viewer
Location:
15; 15 A1
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6737827..6829882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6708349..6800401)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (6658381..6750401)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 9 Neighboring gene FYN binding protein Neighboring gene predicted gene 2245 Neighboring gene prohibitin pseudogene Neighboring gene predicted gene, 53882 Neighboring gene oncostatin M receptor Neighboring gene predicted gene, 41261 Neighboring gene predicted gene, 30559

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rapamycin-insensitive companion of mTOR
Names
AVO3 homolog
mAVO3
protein pianissimo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030168.3NP_084444.3  rapamycin-insensitive companion of mTOR

    See identical proteins and their annotated locations for NP_084444.3

    Status: VALIDATED

    Source sequence(s)
    AI854883, AK036149, AK173326, BC120903
    Consensus CDS
    CCDS37032.1
    UniProtKB/Swiss-Prot
    Q6QI06
    Related
    ENSMUSP00000051809.7, ENSMUST00000061656.8
    Conserved Domains (5) summary
    pfam14663
    Location:747853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:60437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:10841187
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:525740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922988
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    6737827..6829882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520003.2XP_006520066.1  rapamycin-insensitive companion of mTOR isoform X1

    Conserved Domains (5) summary
    pfam14663
    Location:747853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:60437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:10851187
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:637740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922988
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
  2. XM_036159639.1XP_036015532.1  rapamycin-insensitive companion of mTOR isoform X2

    Conserved Domains (5) summary
    pfam14663
    Location:465571
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:14155
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:803905
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:355458
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:640709
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

RNA

  1. XR_004938879.1 RNA Sequence

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