mys myospheroid [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mysprovided by FlyBase
Official Full Name: myospheroidprovided by FlyBase
Primary source: FLYBASE:FBgn0004657
Locus tag: Dmel_CG1560
See related: AllianceGenome:FB:FBgn0004657
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: beta integrin; beta-int; beta-Int; beta-integrin; beta-Integrin; beta-PS; beta-PS-integrin; beta1; betaInt; betamys; betaPS; BetaPS; betaPS Int; betaPS integrin; BetaPS-Int; betaPS-integrin; betaPS-Integrin; betaPS1; beta[[mys]]; beta[[PS]]; beta[[PS]]-integrin; beta[[P]]S; bPS; b[[PS]]; CG1560; CT40473; Dmel\CG1560; EM28; Integrin beta; integrin beta[[PS]]; ItgbPS; l(1)7Db; l(1)7Dn; l(1)93p; l(1)968; l(1)DA551; l(1)EM28; l(1)G0233; l(1)G0281; l(1)mys; MAb6G11; Mys; nj42; olfC; PS; PS integrin; PSbeta; PS[[beta]]
Summary: Enables protein heterodimerization activity. Contributes to extracellular matrix protein binding activity. Involved in several processes, including actin cytoskeleton organization; animal organ development; and open tracheal system development. Located in several cellular components, including costamere; focal adhesion; and synaptic membrane. Is integral component of plasma membrane. Part of integrin complex. Is expressed in several structures, including embryonic brain; gonad; gut section; imaginal disc; and muscle attachment site. Human ortholog(s) of this gene implicated in several diseases, including amelogenesis imperfecta type 1H; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); coronary artery disease (multiple); and leukocyte adhesion deficiency (multiple). Orthologous to several human genes including ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 7D5-7D5; 1-22 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8061645..8070237)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7955678..7964270)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The exit of axons and glial membrane from the developing Drosophila retina requires integrins.
Title: The exit of axons and glial membrane from the developing Drosophila retina requires integrins.
Integrin beta1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells.
Title: Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells.
integrin function is dispensable for pre-follicle cell polarity but is required to maintain cellular organisation and cell shape during morphogenesis.
Title: The role of integrins in Drosophila egg chamber morphogenesis.
Drosophila WASH has conserved functions in integrin receptor recycling and lysosome neutralization.
Title: Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization.
plays role in innate immune responses against viral infection
Title: Protection of Insects against Viral Infection by Apoptosis-Dependent Phagocytosis.
Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH, and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
Title: Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis.
The different arrangements of the talin molecule relative to integrins suggest that talin is able to sense different force vectors, either parallel or perpendicular to the membrane.
Title: Alternative mechanisms for talin to mediate integrin function.
alphaPS1betaPS integrin controls salivary gland migration through Rac1 GTPase which downregulates E-cadherin in proximal and distal gland cells.
Title: Rac1 GTPase acts downstream of αPS1βPS integrin to control collective migration and lumen size in the Drosophila salivary gland.
We identify a role for the alphaPS3, betaPS1 Integrin dimer in both the early establishment of the apical, pre-luminal domain, as well as a requirement upon Robo for maintained apicalisation of proteins required for lumen formation.
Title: Integrins are required for cardioblast polarisation in Drosophila.
analysis of integrin beta subunit mutations that alter affinity for extracellular matrix ligand
Title: Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to extracellular matrix protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in calcium-dependent cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal trunk growth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of epithelial integrity, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate-dependent cell migration, cell extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: myospheroid

Names: CG1560-PA; CG1560-PB; CG1560-PC; CG1560-PD; Integrin-betaPS; Myospheroid/betaPS integrin; PS integrin beta subunit; PS-beta-integrin; PSbeta-integrin; beta PS integrin; beta integrin; beta-PS integrin; beta-PS-Integrin; beta-PS1 integrin; beta-integrin; beta1 integrin; beta1-integrin; betaIntegrin; betaPS; betaPS integrin; betaPS integrin subunit; betaPS-Integrin; betaPS.*integrin; beta[[PS]] integrin; beta[[PS]] integrin subunit; beta[[PS]]-integrin; beta[[mys]]-integrin; integrin; integrin PSbeta; integrin beta; integrin beta1; integrin betaPS subunit; integrin beta[[PS]] subunit; integrin betaps; integrinbeta; lethal myospheroid; lethal(1)93 pupal; lethal(1)myospheroid; myo-spheroid; myospheriod; mys-PA; mys-PB; mys-PC; mys-PD; non-jumper-42; olfactory C; olfactory-C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8061645..8070237

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298070.1 → NP_001284999.1 myospheroid, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284999.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11584, Q8MYX9, Q9W3L2

UniProtKB/TrEMBL

X2JAU0

Conserved Domains (3) summary

smart00187
Location:45 → 505

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:692 → 773

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:803 → 843

Integrin_b_cyt; Integrin beta cytoplasmic domain
NM_001298069.1 → NP_001284998.1 myospheroid, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284998.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11584, Q8MYX9, Q9W3L2

UniProtKB/TrEMBL

X2JAU0

Conserved Domains (3) summary

smart00187
Location:45 → 505

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:692 → 773

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:803 → 843

Integrin_b_cyt; Integrin beta cytoplasmic domain
NM_080054.3 → NP_524793.2 myospheroid, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524793.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P11584, Q8MYX9, Q9W3L2

UniProtKB/TrEMBL

X2JAU0

Related

FBpp0071061

Conserved Domains (3) summary

smart00187
Location:45 → 505

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:692 → 773

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:803 → 843

Integrin_b_cyt; Integrin beta cytoplasmic domain
NM_001298068.1 → NP_001284997.1 myospheroid, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284997.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JE30

Conserved Domains (3) summary

smart00187
Location:45 → 505

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:692 → 773

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:803 → 843

Integrin_b_cyt; Integrin beta cytoplasmic domain