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    Dev Biol. 2010 Apr 15;340(2):504-17. Epub 2010 Feb 10.

    Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.

    Fraichard S, Bougé AL, Kendall T, Chauvel I, Bouhin H, Bunch TA.

    Source

    Centre des Sciences du Goût et de l'Alimentation, UMR-6265 CNRS, INRA, Université de Bourgogne, Agrosup Dijon, F-21000 Dijon, France.

    Abstract

    Morphogenesis of the adult structures of holometabolous insects is regulated by ecdysteroids and juvenile hormones and involves cell-cell interactions mediated in part by the cell surface integrin receptors and their extracellular matrix (ECM) ligands. These adhesion molecules and their regulation by hormones are not well characterized. We describe the gene structure of a newly described ECM molecule, tenectin, and demonstrate that it is a hormonally regulated ECM protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin's function as a new ligand of the PS2 integrins is demonstrated by both genetic interactions in the fly and by cell spreading and cell adhesion assays in cultured cells. Its interaction with the PS2 integrins is dependent on RGD and RGD-like motifs. Tenectin's function in looping morphogenesis in the development of the male genitalia led to experiments that demonstrate a role for PS integrins in the execution of left-right asymmetry.

    Copyright (c) 2010 Elsevier Inc. All rights reserved.

    PMID:
    20152825
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2854234
    Free PMC Article

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