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    E2f3 E2F transcription factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291105, updated on 4-Apr-2024

    Summary

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    Symbol
    E2f3provided by RGD
    Full Name
    E2F transcription factor 3provided by RGD
    Primary source
    RGD:1561600
    See related
    Ensembl:ENSRNOG00000029273 AllianceGenome:RGD:1561600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561600
    Summary
    Predicted to enable DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of vascular associated smooth muscle cell apoptotic process; and protein import into nucleus. Predicted to act upstream of or within positive regulation of cell population proliferation and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human E2F3 (E2F transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 37.2), Spleen (RPKM 34.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See E2f3 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (34810355..34887725)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (34601756..34679139)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (36334136..36408831)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene U2 spliceosomal RNA Neighboring gene non-POU domain containing, octamer-binding, pseudogene 6 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein L37-like 3 Neighboring gene CDK5 regulatory subunit associated protein 1-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study. Xu Y, et al. Oncotarget, 2016 Sep 20. PMID 27557513, Free PMC Article
    2. MicroRNA‑141 inhibits the differentiation of bone marrow‑derived mesenchymal stem cells in steroid‑induced osteonecrosis via E2F3. Xue F, et al. Mol Med Rep, 2022 Jul. PMID 35616132, Free PMC Article
    3. Long noncoding RNA MAPKAPK5-AS1 promoted lipopolysaccharide-induced inflammatory damage in the myocardium by sponging microRNA-124-3p/E2F3. Chen W, et al. Mol Med, 2021 Oct 19. PMID 34666672, Free PMC Article
    4. Critical functions of microRNA-30a-5p-E2F3 in cardiomyocyte apoptosis induced by hypoxia/reoxygenation. Lv XB, et al. Kaohsiung J Med Sci, 2021 Feb. PMID 33058540
    5. Knockdown of E2F3 Inhibits Proliferation, Migration, and Invasion and Increases Apoptosis in Glioma Cells. Shen ZG, et al. Oncol Res, 2017 Nov 2. PMID 28337965, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA141 inhibits the differentiation of bone marrowderived mesenchymal stem cells in steroidinduced osteonecrosis via E2F3.
      Title: MicroRNA‑141 inhibits the differentiation of bone marrow‑derived mesenchymal stem cells in steroid‑induced osteonecrosis via E2F3.
    2. Long noncoding RNA MAPKAPK5-AS1 promoted lipopolysaccharide-induced inflammatory damage in the myocardium by sponging microRNA-124-3p/E2F3.
      Title: Long noncoding RNA MAPKAPK5-AS1 promoted lipopolysaccharide-induced inflammatory damage in the myocardium by sponging microRNA-124-3p/E2F3.
    3. Critical functions of microRNA-30a-5p-E2F3 in cardiomyocyte apoptosis induced by hypoxia/reoxygenation.
      Title: Critical functions of microRNA-30a-5p-E2F3 in cardiomyocyte apoptosis induced by hypoxia/reoxygenation.
    4. E2F transcription factor genes and their 34 target genes have a role in liver regeneration.
      Title: Analysis of the relevance of e2fs and their target genes with rat liver regeneration.
    5. E2F2, unlike E2F1, E2F3 and E2F5, does not induce apoptosis but even suppresses expression of several pro-apoptotic genes in primary cardiomyocytes; E2F1, E2F2, and E2F3 and E2F4 induce S-phase entry of primary cardiomyocytes
      Title: Making omelets without breaking eggs: E2F-mediated induction of cardiomyoycte cell proliferation without stimulation of apoptosis.
    6. 2-Acetylaminofluorene could possibly block G1/S-transition smf slter lelvels of E2f3.
      Title: Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor E2F3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137626.3 → NP_001131098.2  transcription factor E2F3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2K0V6
      Related
      ENSRNOP00000071597.2, ENSRNOT00000081368.2
      Conserved Domains (2) summary
      cd14660
      Location:247 → 347
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:173 → 236
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      34810355..34887725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095507.2 → XP_038951435.1  transcription factor E2F3 isoform X6

      Conserved Domains (3) summary
      cd14660
      Location:247 → 282
      E2F_DD; coiled coil [structural motif]
      pfam02319
      Location:173 → 236
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      cl22411
      Location:247 → 289
      E2F_DD; Dimerization domain of E2F transcription factors

    2. XM_039095500.2 → XP_038951428.1  transcription factor E2F3 isoform X1

      Conserved Domains (2) summary
      cd14660
      Location:241 → 341
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:167 → 230
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    3. XM_039095506.2 → XP_038951434.1  transcription factor E2F3 isoform X5

      Conserved Domains (2) summary
      cd14660
      Location:123 → 223
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:49 → 112
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    4. XM_039095505.2 → XP_038951433.1  transcription factor E2F3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JTE8
      Related
      ENSRNOP00000068682.2
      Conserved Domains (2) summary
      cd14660
      Location:129 → 229
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:55 → 118
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    5. XM_039095503.2 → XP_038951431.1  transcription factor E2F3 isoform X2

      Conserved Domains (2) summary
      cd14660
      Location:158 → 258
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:84 → 147
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    6. XM_039095504.2 → XP_038951432.1  transcription factor E2F3 isoform X3

      Conserved Domains (2) summary
      cd14660
      Location:152 → 252
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:78 → 141
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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