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E2f3 E2F transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 13557, updated on 5-Jan-2023

Summary

Official Symbol
E2f3provided by MGI
Official Full Name
E2F transcription factor 3provided by MGI
Primary source
MGI:MGI:1096340
See related
Ensembl:ENSMUSG00000016477 AllianceGenome:MGI:1096340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E2F3b; E2f3a
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Involved in negative regulation of fat cell proliferation. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human E2F3 (E2F transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.4), limb E14.5 (RPKM 7.5) and 26 other tissues See more
Orthologs
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Genomic context

See E2f3 in Genome Data Viewer
Location:
13; 13 A3.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30090558..30171172, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (29906575..29986064, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53781 Neighboring gene CDK5 regulatory subunit associated protein 1-like 1 Neighboring gene predicted gene, 52084 Neighboring gene predicted gene, 40860 Neighboring gene predicted gene, 23206 Neighboring gene membrane bound O-acyltransferase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0075

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289920.1NP_001276849.1  transcription factor E2F3 isoform E2f3b

    See identical proteins and their annotated locations for NP_001276849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as E2f3b) differs in the 5' UTR and the 5' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform E2f3b, which is shorter and has a distinct N-terminus, compared to isoform E2f3a.
    Source sequence(s)
    AK129048, AK133828, AL513025, BQ176318, BU705601
    Consensus CDS
    CCDS88434.1
    UniProtKB/TrEMBL
    A0A6P5QWQ0, Q3TMJ9, Q3UZJ0, Q6ZQJ8
    Related
    ENSMUSP00000152368.2, ENSMUST00000222730.2
    Conserved Domains (2) summary
    cd14660
    Location:123223
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:49112
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  2. NM_001359994.1NP_001346923.1  transcription factor E2F3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL513025
    Consensus CDS
    CCDS88435.1
    UniProtKB/TrEMBL
    A0A1Y7VML1, A0A6P7QCR5, A0A8C6GCX1
    Related
    ENSMUSP00000152782.2, ENSMUST00000221536.2
    Conserved Domains (2) summary
    cd14660
    Location:129229
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:55118
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  3. NM_010093.3NP_034223.1  transcription factor E2F3 isoform E2f3a

    See identical proteins and their annotated locations for NP_034223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as E2f3a) represents the longer transcript and encodes the longer isoform (E2f3a).
    Source sequence(s)
    AK133828, AV509156, BC059262
    Consensus CDS
    CCDS26413.1
    UniProtKB/Swiss-Prot
    O35261, Q5T0I6
    UniProtKB/TrEMBL
    A0A8C6GC97, Q3UZJ0, Q6PCM3
    Related
    ENSMUSP00000100012.4, ENSMUST00000102948.11
    Conserved Domains (2) summary
    cd14660
    Location:246346
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:172235
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    30090558..30171172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247136.2XP_030102996.1  transcription factor E2F3 isoform X3

    Conserved Domains (2) summary
    cd14660
    Location:240340
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:165229
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  2. XM_011244276.4XP_011242578.1  transcription factor E2F3 isoform X2

    Conserved Domains (2) summary
    cd14660
    Location:250350
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:175239
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  3. XM_011244275.4XP_011242577.1  transcription factor E2F3 isoform X1

    Conserved Domains (2) summary
    cd14660
    Location:256356
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:181245
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  4. XM_036157843.1XP_036013736.1  transcription factor E2F3 isoform X4

    Conserved Domains (2) summary
    cd14660
    Location:144244
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:70133
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain