ACTA2 actin alpha 2, smooth muscle [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: ACTA2
Gene description: actin alpha 2, smooth muscle
See related: Ensembl:ENSOCUG00000008193
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	18	NC_067391.1 (33776331..33793315, complement)

Chromosome 18 - NC_067391.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067391.1 Chromosome 18 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TnT has a previously unrecognized role in forming the inactive state of regulated actin.
Title: The C-terminus of troponin T is essential for maintaining the inactive state of regulated actin.
The terminal pointed end subunit is tilted towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.
Title: Structural basis for the slow dynamics of the actin filament pointed end.
There was no significant change in the expression of TGF-beta(2) and alpha-SMA after laser-assisted intrastromal scanning.
Title: [The expression of Ki-67, TGF-beta(2) and alpha-SMA after the femtosecond laser-assisted intrastromal scanning in rabbit cornea].
The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.
Title: Structure of a longitudinal actin dimer assembled by tandem w domains: implications for actin filament nucleation.
The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.
Title: Comparative expression of laminin and smooth muscle actin in the testis and epididymis of poultry and rabbit.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC23952P1 (e-PCR)
- UniSTS:272216

PMC356969P12 (e-PCR)
- UniSTS:273274

PMC117352P1 (e-PCR)
- UniSTS:270329

General protein information

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Preferred Names: actin, aortic smooth muscle

Names: actin, alpha 2, smooth muscle, aorta; alpha-actin-2; alpha-smooth muscle actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.