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Acta2 actin alpha 2, smooth muscle, aorta [ Mus musculus (house mouse) ]

Gene ID: 11475, updated on 31-Jan-2023

Summary

Official Symbol
Acta2provided by MGI
Official Full Name
actin alpha 2, smooth muscle, aortaprovided by MGI
Primary source
MGI:MGI:87909
See related
Ensembl:ENSMUSG00000035783 AllianceGenome:MGI:87909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Actvs; a-SMA; SMAalpha; SMalphaA; alphaSMA; 0610041G09Rik
Summary
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in smooth muscle. [provided by RefSeq, Feb 2021]
Expression
Biased expression in bladder adult (RPKM 2693.2), ovary adult (RPKM 563.6) and 10 other tissues See more
Orthologs
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Genomic context

See Acta2 in Genome Data Viewer
Location:
19; 19 C1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34217736..34232985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34240336..34255585, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene lipase, family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene STAM binding protein like 1 Neighboring gene predicted gene, 31355 Neighboring gene Fas (TNF receptor superfamily member 6)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in smooth muscle contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin, aortic smooth muscle
Names
actin, alpha, vascular smooth muscle
alpha-actin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007392.3NP_031418.1  actin, aortic smooth muscle

    See identical proteins and their annotated locations for NP_031418.1

    Status: REVIEWED

    Source sequence(s)
    AC102285, AK017374
    Consensus CDS
    CCDS29757.1
    UniProtKB/Swiss-Prot
    P62737
    UniProtKB/TrEMBL
    A0A6P5P700, A0A8C6MQW8
    Related
    ENSMUSP00000048218.9, ENSMUST00000039631.10
    Conserved Domains (1) summary
    PTZ00281
    Location:3377
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34217736..34232985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526606.2XP_006526669.1  actin, aortic smooth muscle isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:3280
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily