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purB adenylosuccinate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945695, updated on 2-May-2024

Summary

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Gene symbol
purB
Gene description
adenylosuccinate lyase
Primary source
ASAP:ABE-0003810
Locus tag
b1131
See related
ECOCYC:EG11314
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ade; ade(h); ECK1117
Summary
HT_Cmplx33_Cyt: [More information is available at EcoGene: EG11314].
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Genomic context

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Sequence:
NC_000913.3 (1190616..1191986, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal protein L16-arginine 3-hydroxylase Neighboring gene sensor histidine kinase PhoQ Neighboring gene DNA-binding transcriptional dual regulator PhoP Neighboring gene lysogenization regulator Neighboring gene tRNA-specific 2-thiouridylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid. Kozlov G, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Sep 1. PMID 19724117, Free PMC Article
  2. Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism. Tsai M, et al. J Mol Biol, 2007 Jul 13. PMID 17531264, Free PMC Article
  3. Mismatch repair in the antimutator Escherichia coli mud. Dzidić S, et al. Mutat Res, 2003 Jan 28. PMID 12517409
  4. The antimutator phenotype of E. coli mud is only apparent and results from delayed appearance of mutants. Schaaper RM, et al. Mutat Res, 2001 Sep 1. PMID 11506800
  5. Nalidixic acid-resistant auxotrophs of Escherichia coli. Helling RB, et al. J Bacteriol, 1970 Nov. PMID 4923064, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR.
  2. crystal structures of wild-type Escherichia coli ADL (ec-ADL), and mutant-substrate (H171A-ADS) and -product (H171N-AMP.FUM) complexes to 2.0, 1.85, and 2.0 A resolution, respectively
    Title: Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylosuccinate lyase
NP_415649.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1190616..1191986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415649.1 adenylosuccinate lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415649.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AKC3, A0A6C9QCA4, A0A6M9WRH6, A0A8S7B013
    Conserved Domains (1) summary
    PRK09285
    Location:1 → 456
    PRK09285; adenylosuccinate lyase; Provisional
Nucleotide Protein
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Gene LinkOut

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