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    ING5 inhibitor of growth family, member 5 [ Homo sapiens ]

    Gene ID: 84289, updated on 11-May-2012
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    Summary

    Official Symbol
    ING5provided by HGNC
    Official Full Name
    inhibitor of growth family, member 5provided by HGNC
    Primary source
    HGNC:19421
    See related
    Ensembl:ENSG00000168395; HPRD:16348; MIM:608525; Vega:OTTHUMG00000151501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p28ING5; FLJ23842
    Summary
    The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q37.3
    Sequence :
    Chromosome: 2; NC_000002.11 (242641456..242668896)
    See ING5 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene ATG4 autophagy related 4 homolog B (S. cerevisiae) Neighboring gene deoxythymidylate kinase (thymidylate kinase) Neighboring gene D-2-hydroxyglutarate dehydrogenase Neighboring gene galactose-3-O-sulfotransferase 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Avvakumov N, et al. Mol Cell Biol, 2012 Feb. PMID 22144582.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. Zhang F, et al. PLoS One, 2011. PMID 21750715.
    4. The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas. Zheng HC, et al. Hum Pathol, 2011 Mar. PMID 21193223.
    5. EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5. Saha A, et al. J Virol, 2011 Mar. PMID 21177815.

    See all (26) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.
      Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.
    2. EBNA3C negatively regulate p53-mediated functions by interacting with ING4 and ING5.
      Title: EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5.
    3. Aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas.
      Title: The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas.
    4. ). Survival analysis indicated that nuclear ING5 was closely linked to favorable prognosis of carcinoma patients (P < .05), albeit not independent.
      Title: The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.
    5. Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion.
      Title: Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma.
    6. ING5 may function as a tumor suppressor gene or oncogene tightly linked with p53 status, and may play an important role in the prognosis of head and neck squamous cell carcinoma (HNSCC) patients.
      Title: Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Tumor-specific mutation and down-regulation of ING5 mRNA suggested it as a tumor suppressor gene in oral squamous cell carcinoma
      Title: Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma.
    9. the PHD domain of ING5 has the characteristic tertiary fold of a zinc finger.
      Title: The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide.
    10. p29ING4 and p28ING5 may be significant modulators of p53 function.
      Title: p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_115705.2 NP_001420.1 EP300    BIND  PubMed p300 interacts with p28ING5. 
    NP_115705.2 NP_000537.2 TP53    BIND  PubMed p53 interacts with p28ING5. 
    Q8WYH8 Q99728 BARD1    HPRD  PubMed  
    Q8WYH8 Q09472 EP300    HPRD  PubMed  
    Q8WYH8 P23434 GCSH    HPRD  PubMed  
    Q8WYH8 P54257 HAP1    HPRD  PubMed  
    Q8WYH8 Q9P2H0 KIAA1377    HPRD  PubMed  
    Q8WYH8 Chromosome 19 open reading frame 50 KXD1    HPRD  PubMed  
    Q8WYH8 Q14566 MCM6    HPRD  PubMed  
    Q8WYH8 Q8IVL1 NAV2    HPRD  PubMed  
    Q8WYH8 Q15154 PCM1    HPRD  PubMed  
    Q8WYH8 O75528 TADA3    HPRD  PubMed  
    Q8WYH8 P04637 TP53    HPRD  PubMed  
    Q8WYH8 P08670 VIM    HPRD  PubMed  
    BioGRID:124016 BioGRID:106821 APC    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:117273 BRD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124016 BioGRID:113614 BRPF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:124016 BioGRID:118036 BRPF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124016 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124016 BioGRID:122742 FAM118B    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:108923 GCSH    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124016 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124016 BioGRID:113703 KAT6A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:124016 BioGRID:117069 KAT6B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:124016 BioGRID:116315 KAT7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:124016 BioGRID:122501 KXD1    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:110339 MCM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124016 BioGRID:110341 MCM4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124016 BioGRID:110343 MCM6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:124016 BioGRID:122280 MEAF6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:124016 BioGRID:110390 MEST    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:124606 NAV2    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:111139 PCM1    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:116924 PHF15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124016 BioGRID:115113 PHF16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124016 BioGRID:123029 PHF17    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:124016 BioGRID:122548 TAF1D    BioGRID  PubMed Two-hybrid 
    BioGRID:124016 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ING5 gene: The ING5 gene is conserved in chimpanzee, , dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , and S.pombe.
    • Map Viewer (Mouse)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    methylated histone residue binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    inhibitor of growth protein 5
    Names
    inhibitor of growth protein 5
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032329.4 → NP_115705.2  inhibitor of growth protein 5

      Status: REVIEWED

      Source sequence(s)
      AF189286, AI701412, AK074422, AK128322, BC039028, BI962551, BQ187350
      Consensus CDS
      CCDS33425.1
      UniProtKB/Swiss-Prot
      Q8WYH8
      Related
      ENSP00000322142, OTTHUMP00000200119, ENST00000313552, OTTHUMT00000322901
      Conserved Domains (2) summary
      pfam12998
      Location:5 – 107
      Blast Score: 336
      ING; Inhibitor of growth proteins N-terminal histone-binding
      cl15348
      Location:189 – 235
      Blast Score: 109
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      242641456..242668896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      234396720..234424015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC114730.5 AAX82019.1
    genomic AC133528.4 AAY14921.1
    genomic CH471063.1 EAW71287.1
      EAW71288.1
      EAW71289.1
    mRNA AF189286.1 AAL68979.1
    mRNA AI701412.1 None
    mRNA AK074422.1 BAB85078.1
    mRNA AK128322.1 None
    mRNA AK289958.1 BAF82647.1
    mRNA BC005370.1 AAH05370.1
    mRNA BC039028.1 None
    mRNA BC071899.1 AAH71899.1
    mRNA BI962551.1 None
    mRNA BQ187350.1 None
    other-genetic HQ447553.1 ADQ32039.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WYH8.1 GenPept UniProtKB/Swiss-Prot:Q8WYH8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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