gabra5 gamma-aminobutyric acid type A receptor subunit alpha5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gabra5provided by ZNC
Official Full Name: gamma-aminobutyric acid type A receptor subunit alpha5provided by ZNC
Primary source: ZFIN:ZDB-GENE-081104-30
See related: Ensembl:ENSDARG00000070730 AllianceGenome:ZFIN:ZDB-GENE-081104-30
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-93p24.1
Summary: Predicted to enable GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within chloride transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Predicted to be integral component of plasma membrane. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (38365743..38426891, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (38368221..38429381, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABAA alpha subunit control of hyperactive behavior in developing zebrafish.
Title: GABAA α subunit control of hyperactive behavior in developing zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fb77b05.x1 (e-PCR)
- UniSTS:187526

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: gamma-aminobutyric acid receptor subunit alpha-5

Names: gamma-aminobutyric acid (GABA) A receptor, alpha 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

38365743..38426891 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477199.1 → XP_021332874.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

UniProtKB/TrEMBL

A0A8M9QG82, E9QE70, F1QZ29

Related

ENSDARP00000117315.1, ENSDART00000138026.2

Conserved Domains (1) summary

cl27321
Location:19 → 442

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
XM_021477200.1 → XP_021332875.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

UniProtKB/TrEMBL

A0A8M9QG82, E9QE70, F1QZ29

Related

ENSDARP00000094910.5, ENSDART00000104135.5

Conserved Domains (1) summary

cl27321
Location:19 → 442

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394659.1 Reference GRCz11 ALT_DRER_TU_1

Range

76234..135783 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166083.4 → XP_005166140.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

See identical proteins and their annotated locations for XP_005166140.1

UniProtKB/TrEMBL

A0A8M9QG82, E9QE70, F1QZ29

Conserved Domains (1) summary

cl27321
Location:19 → 442

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
XM_005166082.4 → XP_005166139.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

See identical proteins and their annotated locations for XP_005166139.1

UniProtKB/TrEMBL

A0A8M9QG82, E9QE70, F1QZ29

Conserved Domains (1) summary

cl27321
Location:19 → 442

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
XM_009302571.3 → XP_009300846.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X2

UniProtKB/TrEMBL

A0A8M3B0L7

Conserved Domains (1) summary

pfam02932
Location:80 → 255

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region