cfap298 cilia and flagella associated protein 298 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cfap298provided by ZNC
Official Full Name: cilia and flagella associated protein 298provided by ZNC
Primary source: ZFIN:ZDB-GENE-040930-8
See related: Ensembl:ENSDARG00000035332 AllianceGenome:ZFIN:ZDB-GENE-040930-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grb; kur; c21orf59; sb:cb615; c21orf59l; zgc:64057; c10h21orf59
Summary: Acts upstream of or within several processes, including central canal development; cerebrospinal fluid circulation; and motile cilium assembly. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Is expressed in several structures, including Kupffer's vesicle; axis; mesoderm; pronephros; and sensory system. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 26. Orthologous to human CFAP298 (cilia and flagella associated protein 298). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (33573838..33579114)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (33629978..33635254)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

On being the right shape: Roles for motile cilia and cerebrospinal fluid flow in body and spine morphology.
Title: On being the right shape: Roles for motile cilia and cerebrospinal fluid flow in body and spine morphology.
c21orf59/kurly controls both cilia motility and polarization in zebrafish and Xenopus.
Title: c21orf59/kurly Controls Both Cilia Motility and Polarization.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within central canal development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebrospinal fluid circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cilium movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cilia- and flagella-associated protein 298

Names: Kurly; UPF0769 protein C21orf59 homolog; c10h21orf59 homolog; c21orf59 homolog, like; protein kurly; unm tj271; unm tm304; unm_tj271

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.