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Mzt1 mitotic spindle organizing protein 1 [ Mus musculus (house mouse) ]

Gene ID: 76789, updated on 8-May-2024

Summary

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Official Symbol
Mzt1provided by MGI
Official Full Name
mitotic spindle organizing protein 1provided by MGI
Primary source
MGI:MGI:1924039
See related
Ensembl:ENSMUSG00000033186 AllianceGenome:MGI:1924039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mozart1; 2410129H14Rik
Summary
Predicted to be involved in gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; and mitotic spindle assembly. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of gamma-tubulin large complex. Predicted to be active in centrosome; interphase microtubule organizing center; and spindle. Is expressed in several structures, including central nervous system and retina. Orthologous to human MZT1 (mitotic spindle organizing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 17.8), CNS E18 (RPKM 17.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mzt1 in Genome Data Viewer
Location:
14 E2.2; 14 49.22 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99271980..99283898, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99034544..99046453, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41228 Neighboring gene predicted gene, 18148 Neighboring gene STARR-seq mESC enhancer starr_37423 Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene bora, aurora kinase A activator Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene Kruppel-like transcription factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in gamma-tubulin complex localization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule nucleation by interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin ring complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitotic-spindle organizing protein 1
Names
mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175245.4 → NP_780454.1  mitotic-spindle organizing protein 1

    See identical proteins and their annotated locations for NP_780454.1

    Status: VALIDATED

    Source sequence(s)
    AK151232, AK169036, BB844588
    Consensus CDS
    CCDS49554.1
    UniProtKB/Swiss-Prot
    Q8BUR9
    Related
    ENSMUSP00000037557.9, ENSMUST00000042662.10
    Conserved Domains (1) summary
    pfam12554
    Location:19 → 64
    MOZART1; Mitotic-spindle organizing gamma-tubulin ring associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    99271980..99283898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248094.2 → XP_030103954.1  mitotic-spindle organizing protein 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUR9.1 GenPept UniProtKB/Swiss-Prot:Q8BUR9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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