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Osgepl1 O-sialoglycoprotein endopeptidase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 72085, updated on 5-Mar-2024

Summary

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Official Symbol
Osgepl1provided by MGI
Official Full Name
O-sialoglycoprotein endopeptidase-like 1provided by MGI
Primary source
MGI:MGI:1919335
See related
Ensembl:ENSMUSG00000026096 AllianceGenome:MGI:1919335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610001M19Rik
Summary
Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Orthologous to human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 8.1), liver E14 (RPKM 5.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Osgepl1 in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53352070..53365502)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53313356..53326343)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00911 Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene predicted gene 28777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:53370474-53370583 Neighboring gene ORM1-like 1 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_00913 Neighboring gene ankyrin and armadillo repeat containing pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2543 Neighboring gene asparagine synthetase domain containing 1 Neighboring gene Asnsd1 upstream reading frame Neighboring gene solute carrier family 39 (zinc transporter), member 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a novel human gene containing ANK repeats and ARM domains. Occhi G, et al. Biochem Biophys Res Commun, 2004 May 21. PMID 15110750
  2. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Jenne DE, et al. Genes Chromosomes Cancer, 2003 Jun. PMID 12696059
  3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC13061

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N(6)-L-threonylcarbamoyladenine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
Names
N6-L-threonylcarbamoyladenine synthase
O-sialoglycoprotein endopeptidase-like protein 1
probable O-sialoglycoprotein endopeptidase 2
probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
t(6)A synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
NP_001272768.1
XP_006496353.1
XP_030098969.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285839.1 → NP_001272768.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001272768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC153650, AK011265, BC030671, BY780319
    Consensus CDS
    CCDS14953.1
    UniProtKB/Swiss-Prot
    Q3UVG1, Q6PEB4, Q8BLB6, Q9D0N0
    Related
    ENSMUSP00000027265.4, ENSMUST00000027265.10
    Conserved Domains (3) summary
    TIGR03723
    Location:39 → 372
    T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD
    cl17037
    Location:40 → 338
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    cl22532
    Location:39 → 145
    Carbam_trans_N; Carbamoyltransferase N-terminus

RNA

  1. NR_104360.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' splice site and lacks an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC153650, BC030671, BY780319
    Related
    ENSMUST00000151296.8

  2. NR_104361.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC153650, AK137332, BY780319
    Related
    ENSMUST00000135614.8

  3. NR_151661.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153650

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    53352070..53365502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496290.5 → XP_006496353.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X1

    Conserved Domains (1) summary
    COG0533
    Location:1 → 245
    TsaD; tRNA A37 threonylcarbamoyltransferase TsaD [Translation, ribosomal structure and biogenesis]

  2. XM_030243109.2 → XP_030098969.1  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform X2

    Conserved Domains (1) summary
    COG0533
    Location:3 → 174
    TsaD; tRNA A37 threonylcarbamoyltransferase TsaD [Translation, ribosomal structure and biogenesis]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028091.3: Suppressed sequence

    Description
    NM_028091.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEB4.2 GenPept UniProtKB/Swiss-Prot:Q6PEB4

Gene LinkOut

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