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MYLK myosin light chain kinase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 715422, updated on 5-Mar-2024

Summary

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Official Symbol
MYLKprovided by VGNC
Official Full Name
myosin light chain kinaseprovided by VGNC
Primary source
VGNC:VGNC:75107
See related
Ensembl:ENSMMUG00000014818
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
38
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (152480878..152701002)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (44843015..45063403, complement)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676416 Neighboring gene rhophilin associated tail protein 1 Neighboring gene coiled-coil domain containing 14 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene uncharacterized LOC114676417 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene adenylate cyclase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables myosin light chain kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tonic smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myosin light chain kinase, smooth muscle
XP_001113525.2
XP_014985500.2
XP_014985501.2
XP_014985502.2
XP_014985504.1
XP_014985505.1
XP_014985506.1
XP_014985507.1
XP_014985509.1
XP_028700411.1
XP_028700412.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    152480878..152701002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001113525.4 → XP_001113525.2  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    F6VWL8, H9FUR0
    Related
    ENSMMUP00000019460.4, ENSMMUT00000020797.4
    Conserved Domains (5) summary
    cd05762
    Location:1238 → 1335
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1461 → 1719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    pfam07679
    Location:1809 → 1899
    I-set; Immunoglobulin I-set domain

  2. XM_015130016.2 → XP_014985502.2  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/TrEMBL
    H9FUR0
    Conserved Domains (5) summary
    cd05762
    Location:1238 → 1335
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1461 → 1719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    pfam07679
    Location:1808 → 1898
    I-set; Immunoglobulin I-set domain

  3. XM_015130014.2 → XP_014985500.2  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    F6VWL8, H9FUR0
    Conserved Domains (5) summary
    cd05762
    Location:1238 → 1335
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1461 → 1719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    pfam07679
    Location:1809 → 1899
    I-set; Immunoglobulin I-set domain

  4. XM_028844578.1 → XP_028700411.1  myosin light chain kinase, smooth muscle isoform X3

    UniProtKB/TrEMBL
    H9FUR0
    Conserved Domains (5) summary
    cd05762
    Location:1238 → 1335
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1461 → 1719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    pfam07679
    Location:161 → 250
    I-set; Immunoglobulin I-set domain

  5. XM_015130015.2 → XP_014985501.2  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    F6VWL8, H9FUR0
    Related
    ENSMMUP00000019461.4, ENSMMUT00000020798.4
    Conserved Domains (5) summary
    cd05762
    Location:1238 → 1335
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:1331 → 1423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1461 → 1719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 412
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    pfam07679
    Location:1809 → 1899
    I-set; Immunoglobulin I-set domain

  6. XM_015130018.2 → XP_014985504.1  myosin light chain kinase, smooth muscle isoform X5

    UniProtKB/TrEMBL
    H9F768
    Conserved Domains (4) summary
    cd05762
    Location:38 → 135
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:131 → 223
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:609 → 699
    I-set; Immunoglobulin I-set domain
    cl21453
    Location:261 → 519
    PKc_like; Protein Kinases, catalytic domain

  7. XM_028844579.1 → XP_028700412.1  myosin light chain kinase, smooth muscle isoform X4

    UniProtKB/TrEMBL
    H9F768
    Conserved Domains (4) summary
    cd05762
    Location:89 → 186
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:182 → 274
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:660 → 750
    I-set; Immunoglobulin I-set domain
    cl21453
    Location:312 → 570
    PKc_like; Protein Kinases, catalytic domain

  8. XM_015130019.2 → XP_014985505.1  myosin light chain kinase, smooth muscle isoform X6

    Conserved Domains (4) summary
    smart00408
    Location:310 → 377
    IGc2; Immunoglobulin C-2 Type
    pfam07679
    Location:297 → 387
    I-set; Immunoglobulin I-set domain
    pfam00069
    Location:1 → 207
    Pkinase; Protein kinase domain
    cl21453
    Location:1 → 207
    PKc_like; Protein Kinases, catalytic domain

  9. XM_015130020.2 → XP_014985506.1  myosin light chain kinase, smooth muscle isoform X9

    Conserved Domains (3) summary
    smart00408
    Location:179 → 246
    IGc2; Immunoglobulin C-2 Type
    pfam07679
    Location:166 → 256
    I-set; Immunoglobulin I-set domain
    cl21453
    Location:1 → 76
    PKc_like; Protein Kinases, catalytic domain

  10. XM_015130021.2 → XP_014985507.1  myosin light chain kinase, smooth muscle isoform X7

    Conserved Domains (1) summary
    cd20973
    Location:52 → 139
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

  11. XM_015130023.2 → XP_014985509.1  myosin light chain kinase, smooth muscle isoform X8

    Conserved Domains (1) summary
    cd20973
    Location:51 → 138
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
Nucleotide Protein
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