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Vstm5 V-set and transmembrane domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 69137, updated on 18-Sep-2024

Summary

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Official Symbol
Vstm5provided by MGI
Official Full Name
V-set and transmembrane domain containing 5provided by MGI
Primary source
MGI:MGI:1916387
See related
Ensembl:ENSMUSG00000031937 AllianceGenome:MGI:1916387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2200002K05Rik
Summary
Involved in filopodium assembly; positive regulation of excitatory synapse assembly; and protein homooligomerization. Acts upstream of or within ventral spinal cord development. Located in axon; dendrite; and plasma membrane. Is integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; gut; and urinary system. Orthologous to human VSTM5 (V-set and transmembrane domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 16.5), large intestine adult (RPKM 15.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A2; 9 4.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15150197..15170717)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15238901..15259421)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22658 Neighboring gene STARR-seq mESC enhancer starr_23369 Neighboring gene STARR-seq mESC enhancer starr_23370 Neighboring gene predicted gene, 39293 Neighboring gene predicted gene, 51702 Neighboring gene STARR-seq mESC enhancer starr_23372 Neighboring gene mediator complex subunit 17 Neighboring gene RIKEN cDNA 4931406C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E6715 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses. Oludada OE, et al. Biochem Biophys Res Commun, 2022 Dec 20. PMID 36308908
  2. Differential effects of N-linked glycosylation of Vstm5 at multiple sites on surface expression and filopodia formation. Lee AR, et al. PLoS One, 2017. PMID 28746350, Free PMC Article
  3. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Kim HR, et al. Nat Commun, 2018 Sep 7. PMID 30194420, Free PMC Article
  4. Putative Cell Adhesion Membrane Protein Vstm5 Regulates Neuronal Morphology and Migration in the Central Nervous System. Lee AR, et al. J Neurosci, 2016 Sep 28. PMID 27683913, Free PMC Article
  5. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses.
    Title: VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses.
  2. Data indicate that four N-linked glycosylation sites (Asn43, Asn87, Asn101, and Asn108) are predicted to be located in the extracellular N-terminus of V-set and transmembrane domain-containing protein 5 (Vstm5), but their functional roles may not be identical.
    Title: Differential effects of N-linked glycosylation of Vstm5 at multiple sites on surface expression and filopodia formation.
  3. In this study, we demonstrate for the first time that V-set and transmembrane domain-containing protein 5 (Vstm5), a putative cell adhesion membrane protein, modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics.
    Title: Putative Cell Adhesion Membrane Protein Vstm5 Regulates Neuronal Morphology and Migration in the Central Nervous System.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of excitatory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of excitatory synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ventral spinal cord development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
V-set and transmembrane domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026955.2 → NP_081231.1  V-set and transmembrane domain-containing protein 5 precursor

    See identical proteins and their annotated locations for NP_081231.1

    Status: PROVISIONAL

    Source sequence(s)
    AK034938
    Consensus CDS
    CCDS22833.1
    UniProtKB/Swiss-Prot
    Q9D806
    Related
    ENSMUSP00000034413.7, ENSMUST00000034413.8
    Conserved Domains (1) summary
    cl11960
    Location:43 → 137
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15150197..15170717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242595.3 → XP_011240897.1  V-set and transmembrane domain-containing protein 5 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:48 → 137
    Ig; Immunoglobulin domain

  2. XM_011242596.3 → XP_011240898.1  V-set and transmembrane domain-containing protein 5 isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:48 → 137
    Ig; Immunoglobulin domain

RNA

  1. XR_379133.4 RNA Sequence

  2. XR_870538.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D806.1 GenPept UniProtKB/Swiss-Prot:Q9D806

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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