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Fam168b family with sequence similarity 168, member B [ Rattus norvegicus (Norway rat) ]

Gene ID: 690188, updated on 13-Apr-2024

Summary

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Official Symbol
Fam168bprovided by RGD
Official Full Name
family with sequence similarity 168, member Bprovided by RGD
Primary source
RGD:1583985
See related
Ensembl:ENSRNOG00000023467 AllianceGenome:RGD:1583985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in axon; perinuclear region of cytoplasm; and plasma membrane. Predicted to be integral component of membrane. Orthologous to human FAM168B (family with sequence similarity 168 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 192.3), Thymus (RPKM 182.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fam168b in Genome Data Viewer
Location:
9q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44501466..44534571, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (37005569..37038631, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41305570..41337536, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene uncharacterized LOC120094663 Neighboring gene small integral membrane protein 39 Neighboring gene uncharacterized LOC120094662 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene U1 spliceosomal RNA Neighboring gene ribosomal protein S14, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterizing the neurite outgrowth inhibitory effect of Mani. Mishra M, et al. FEBS Lett, 2012 Sep 21. PMID 22771904
  2. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myelin-associated neurite-outgrowth inhibitor
Names
mani
protein FAM168B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271134.1 → NP_001258063.1  myelin-associated neurite-outgrowth inhibitor

    See identical proteins and their annotated locations for NP_001258063.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    D4AEP3
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 194
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    44501466..44534571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596648.3 → XP_017452137.1  myelin-associated neurite-outgrowth inhibitor isoform X3

    UniProtKB/TrEMBL
    A0A8L2QHF9
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 201
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. XM_008766978.4 → XP_008765200.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008765200.1

    UniProtKB/TrEMBL
    A0A8L2QHF9
    Related
    ENSRNOP00000033168.6
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 213
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  3. XM_017596649.3 → XP_017452138.1  myelin-associated neurite-outgrowth inhibitor isoform X4

    Conserved Domains (1) summary
    pfam14944
    Location:1 → 174
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  4. XM_008766975.4 → XP_008765197.2  myelin-associated neurite-outgrowth inhibitor isoform X2

    UniProtKB/TrEMBL
    A0A8L2QHF9
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 206
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  5. XM_063267764.1 → XP_063123834.1  myelin-associated neurite-outgrowth inhibitor isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4AEP3.1 GenPept UniProtKB/Swiss-Prot:D4AEP3

Gene LinkOut

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