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Myl4 myosin, light chain 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688228, updated on 17-Aug-2024

Summary

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Official Symbol
Myl4provided by RGD
Official Full Name
myosin, light chain 4provided by RGD
Primary source
RGD:1591197
See related
EnsemblRapid:ENSRNOG00000050675 AllianceGenome:RGD:1591197
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in cardiac muscle contraction; positive regulation of ATPase activity; and regulation of the force of heart contraction. Predicted to be located in A band. Predicted to be part of myosin complex. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1417.0), Lung (RPKM 199.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89949733..89985308)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (89449456..89485365)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (92628356..92638100)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene uncharacterized LOC134480887 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene cell division cycle 27 Neighboring gene glutathione S-transferase pi 1, pseudogene 2 Neighboring gene integrin subunit beta 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation. Zhong Y, et al. Redox Biol, 2023 Apr. PMID 36645977, Free PMC Article
  2. Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats. Peng W, et al. J Am Heart Assoc, 2017 Oct 28. PMID 29080865, Free PMC Article
  3. Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model. Abdelaziz AI, et al. J Mol Med (Berl), 2004 Apr. PMID 14985854
  4. The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function. Timson DJ, et al. Eur J Biochem, 1998 Aug 1. PMID 9738905
  5. Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension. Rovner AS, et al. Nucleic Acids Res, 1990 Mar 25. PMID 2326197, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation.
    Title: Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation.
  2. Loss-of-function MYL4 gene variants cause progressive atrial cardiomyopathy in genetically modified rats.
    Title: Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in A band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in A band ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin light chain 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109495.1 → NP_001102965.1  myosin light chain 4

    See identical proteins and their annotated locations for NP_001102965.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I5YBR7, A6HJW5, M0R4E1
    Conserved Domains (1) summary
    PTZ00184
    Location:45 → 192
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    89949733..89985308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086843.2 → XP_038942771.1  myosin light chain 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBR7, A6HJW5, M0R4E1
    Related
    ENSRNOP00000064224.1, ENSRNOT00000072480.3
    Conserved Domains (1) summary
    PTZ00184
    Location:45 → 192
    PTZ00184; calmodulin; Provisional

  2. XM_039086842.2 → XP_038942770.1  myosin light chain 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBR7, A6HJW5, M0R4E1
    Conserved Domains (1) summary
    PTZ00184
    Location:45 → 192
    PTZ00184; calmodulin; Provisional

  3. XM_039086841.2 → XP_038942769.1  myosin light chain 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBR7, A6HJW5, M0R4E1
    Conserved Domains (1) summary
    PTZ00184
    Location:45 → 192
    PTZ00184; calmodulin; Provisional

  4. XM_039086844.2 → XP_038942772.1  myosin light chain 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBR7, A6HJW5, M0R4E1
    Conserved Domains (1) summary
    PTZ00184
    Location:45 → 192
    PTZ00184; calmodulin; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17209.2 GenPept UniProtKB/Swiss-Prot:P17209

Gene LinkOut

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