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MYL4 myosin light chain 4 [ Homo sapiens (human) ]

Gene ID: 4635, updated on 1-Aug-2020

Summary

Official Symbol
MYL4provided by HGNC
Official Full Name
myosin light chain 4provided by HGNC
Primary source
HGNC:HGNC:7585
See related
Ensembl:ENSG00000198336 MIM:160770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GT1; ALC1; AMLC; PRO1957
Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward heart (RPKM 587.0) See more
Orthologs

Genomic context

See MYL4 in Genome Data Viewer
Location:
17q21.32
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47209017..47227650)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45266728..45301045)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene cell division cycle 27 Neighboring gene ribosomal protein S2 pseudogene 47 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3215 Neighboring gene RNA, U7 small nuclear 186 pseudogene Neighboring gene integrin subunit beta 3 Neighboring gene uncharacterized LOC107985029

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
myosin II heavy chain binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle filament sliding TAS
Traceable Author Statement
more info
 
positive regulation of ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
A band IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
myosin complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin light chain 4
Names
atrial myosin light chain 1
myosin light chain 1, embryonic muscle/atrial isoform
myosin light chain alkali GT-1 isoform
myosin, atrial/fetal muscle, light chain
myosin, light chain 4, alkali; atrial, embryonic
myosin, light polypeptide 4, alkali; atrial, embryonic

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052847.1 RefSeqGene

    Range
    5046..19663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002841.1NP_001002841.1  myosin light chain 4

    See identical proteins and their annotated locations for NP_001002841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    BC030228, BU658678, H83803
    Consensus CDS
    CCDS11510.1
    UniProtKB/Swiss-Prot
    P12829
    Related
    ENSP00000347055.1, ENST00000354968.5
    Conserved Domains (2) summary
    PTZ00184
    Location:49196
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:134195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_002476.2NP_002467.1  myosin light chain 4

    See identical proteins and their annotated locations for NP_002467.1

    Status: REVIEWED

    Source sequence(s)
    X58851
    Consensus CDS
    CCDS11510.1
    UniProtKB/Swiss-Prot
    P12829
    Related
    ENSP00000377096.1, ENST00000393450.5
    Conserved Domains (2) summary
    PTZ00184
    Location:49196
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:134195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    47209017..47227650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024683.1XP_016880172.1  myosin light chain 4 isoform X1

    Conserved Domains (1) summary
    cl25352
    Location:86227
    EFh_PEF; The penta-EF hand (PEF) family
  2. XM_005257391.5XP_005257448.1  myosin light chain 4 isoform X2

    See identical proteins and their annotated locations for XP_005257448.1

    UniProtKB/Swiss-Prot
    P12829
    Related
    ENSP00000461570.1, ENST00000572316.5
    Conserved Domains (2) summary
    PTZ00184
    Location:49196
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:134195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_011524839.2XP_011523141.2  myosin light chain 4 isoform X1

    Conserved Domains (1) summary
    cl25352
    Location:86227
    EFh_PEF; The penta-EF hand (PEF) family
  4. XM_024450766.1XP_024306534.1  myosin light chain 4 isoform X1

    Conserved Domains (1) summary
    cl25352
    Location:86227
    EFh_PEF; The penta-EF hand (PEF) family
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