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Ido2 indoleamine 2,3-dioxygenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 681319, updated on 2-May-2024

Summary

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Official Symbol
Ido2provided by RGD
Official Full Name
indoleamine 2,3-dioxygenase 2provided by RGD
Primary source
RGD:1596771
See related
Ensembl:ENSRNOG00000025365 AllianceGenome:RGD:1596771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IDO-2; Indol1
Summary
Predicted to enable indoleamine 2,3-dioxygenase activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in 'de novo' NAD biosynthetic process from tryptophan and tryptophan catabolic process to kynurenine. Predicted to be active in cytoplasm. Orthologous to human IDO2 (indoleamine 2,3-dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 55.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (74161761..74200651)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67459158..67498052)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (72232852..72291227)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 18 Neighboring gene uncharacterized LOC108348416 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene uncharacterized LOC134482409 Neighboring gene uncharacterized LOC120097515 Neighboring gene transcriptional and immune response regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction. Watts SW, et al. Am J Physiol Heart Circ Physiol, 2011 Oct. PMID 21841011, Free PMC Article
  2. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Ball HJ, et al. Gene, 2007 Jul 1. PMID 17499941
  3. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Metz R, et al. Cancer Res, 2007 Aug 1. PMID 17671174
  4. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Bessede A, et al. Nature, 2014 Jul 10. PMID 24930766, Free PMC Article
  5. The kynurenine pathway and neurodegenerative disease. Maddison DC, et al. Semin Cell Dev Biol, 2015 Apr. PMID 25773161

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables indoleamine 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables indoleamine 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables indoleamine 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tryptophan catabolic process to kynurenine ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan catabolic process to kynurenine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
indoleamine 2,3-dioxygenase 2
Names
indoleamine 2,3-dioxygenase-like protein 1
indoleamine-pyrrole 2,3 dioxygenase-like 1
indoleamine-pyrrole 2,3-dioxygenase-like protein 1
NP_001406603.1
XP_038951143.1
XP_038951145.1
XP_038951146.1
XP_063131794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419674.1 → NP_001406603.1  indoleamine 2,3-dioxygenase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    F1LV46
    Related
    ENSRNOP00000036799.7, ENSRNOT00000032116.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    74161761..74200651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095215.2 → XP_038951143.1  indoleamine 2,3-dioxygenase 2 isoform X1

    Conserved Domains (1) summary
    pfam01231
    Location:15 → 387
    IDO; Indoleamine 2,3-dioxygenase

  2. XM_039095218.2 → XP_038951146.1  indoleamine 2,3-dioxygenase 2 isoform X4

    Conserved Domains (1) summary
    cl21721
    Location:15 → 222
    IDO; Indoleamine 2,3-dioxygenase

  3. XM_063275724.1 → XP_063131794.1  indoleamine 2,3-dioxygenase 2 isoform X3

  4. XM_039095217.2 → XP_038951145.1  indoleamine 2,3-dioxygenase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0N4SWI7
    Conserved Domains (1) summary
    pfam01231
    Location:1 → 334
    IDO; Indoleamine 2,3-dioxygenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LV46.4 GenPept UniProtKB/Swiss-Prot:F1LV46

Gene LinkOut

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