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Rwdd3 RWD domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65026, updated on 18-Sep-2024

Summary

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Official Symbol
Rwdd3provided by RGD
Official Full Name
RWD domain containing 3provided by RGD
Primary source
RGD:620472
See related
EnsemblRapid:ENSRNOG00000029893 AllianceGenome:RGD:620472
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rsume; X2cr1
Summary
Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of hypoxia-inducible factor-1alpha signaling pathway; and positive regulation of protein sumoylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human RWDD3 (RWD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 38.0), Lung (RPKM 36.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (211918361..211933644, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209233622..209254842, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (224710351..224723136, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553943 Neighboring gene U6 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene TLC domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In silico structural and functional characterization of the RSUME splice variants. Gerez J, et al. PLoS One, 2013. PMID 23469069, Free PMC Article
  2. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Carbia-Nagashima A, et al. Cell, 2007 Oct 19. PMID 17956732
  3. RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Shan B, et al. Endocr Relat Cancer, 2012 Feb. PMID 22009797
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of hypoxia-inducible factor-1alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RWD domain-containing protein 3
Names
RWD domain-containing sumoylation enhancer
RWD-containing sumoylation enhancer
pituitary tumor X2CR1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128152.1 → NP_001121624.1  RWD domain-containing protein 3

    See identical proteins and their annotated locations for NP_001121624.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P0C7N0
    UniProtKB/TrEMBL
    A0A8L2QK58, A6HVD1
    Related
    ENSRNOP00000039966.5, ENSRNOT00000040080.6
    Conserved Domains (2) summary
    pfam05773
    Location:3 → 111
    RWD; RWD domain
    pfam06544
    Location:146 → 258
    DUF1115; Protein of unknown function (DUF1115)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    211918361..211933644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103082.2 → XP_038959010.1  RWD domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    pfam05773
    Location:3 → 111
    RWD; RWD domain

  2. XM_039103084.2 → XP_038959012.1  RWD domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam06544
    Location:48 → 160
    DUF1115; Protein of unknown function (DUF1115)

  3. XM_063282502.1 → XP_063138572.1  RWD domain-containing protein 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7N0.1 GenPept UniProtKB/Swiss-Prot:P0C7N0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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