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ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 [ Canis lupus familiaris (dog) ]

Gene ID: 611267, updated on 5-Mar-2024

Summary

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Official Symbol
ADAMTS10provided by VGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 10provided by VGNC
Primary source
VGNC:VGNC:37591
See related
Ensembl:ENSCAFG00845006935
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ADAMTS10 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (53618496..53638525, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (52891920..52907521, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (53498562..53514160, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (52820751..52836351, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (53267203..53282791, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119864761 Neighboring gene zinc finger protein 414 Neighboring gene myosin IF Neighboring gene uncharacterized LOC119864762 Neighboring gene NFIL3 like basic leucine zipper Neighboring gene actin like 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation. Palko JR, et al. PLoS One, 2016. PMID 27271467, Free PMC Article
  2. Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Boote C, et al. Mol Vis, 2016. PMID 27212875, Free PMC Article
  3. Biomechanical properties and correlation with collagen solubility profile in the posterior sclera of canine eyes with an ADAMTS10 mutation. Palko JR, et al. Invest Ophthalmol Vis Sci, 2013 Apr 12. PMID 23518772, Free PMC Article
  4. Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. Kuchtey J, et al. PLoS Genet, 2011 Feb. PMID 21379321, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Despite a mutation that affects the extracellular matrix and a chronic intraocular pressure elevation in the affected dogs, age-associated scleral stiffening and loss of mechanical damping were still prominent and had a similar rate of change as in the normal dogs.
    Title: Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation.
  2. Significant alterations in the posterior scleral collagen microstructure are present before the onset of clinical glaucoma in ADAMTS10 mutant dogs.
    Title: Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation.
  3. An inherently weaker and biochemically distinct posterior sclera was observed in dogs with the G661R missense mutation in ADAMTS10 before clinical indications of optic nerve damage.
    Title: Biomechanical properties and correlation with collagen solubility profile in the posterior sclera of canine eyes with an ADAMTS10 mutation.
  4. The Gly661Arg variant in ADAMTS10 found in the primary open angle glaucoma Beagles suggests that altered processing of extracellular matrix and/or defects in microfibril structure or function may be involved in raising intraocular pressure.
    Title: Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284481.1 → NP_001271410.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor

    See identical proteins and their annotated locations for NP_001271410.1

    Status: PROVISIONAL

    Source sequence(s)
    JX306093
    UniProtKB/TrEMBL
    A0A5F4BXP2, A0A8C0LCQ3, A0A8C0TL48
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1069 → 1101
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    53618496..53638525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426516.1 → XP_038282444.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

    UniProtKB/TrEMBL
    A0A5F4BXP2, A0A8C0LCQ3, A0A8C0TL48
    Related
    ENSCAFP00845009738.1, ENSCAFT00845012465.1
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1069 → 1101
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_038426519.1 → XP_038282447.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

    UniProtKB/TrEMBL
    A0A5F4BXP2, A0A8C0LCQ3, A0A8C0TL48
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1069 → 1101
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_038426520.1 → XP_038282448.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

    UniProtKB/TrEMBL
    A0A5F4BXP2, A0A8C0LCQ3, A0A8C0TL48
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1069 → 1101
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

  4. XM_038426518.1 → XP_038282446.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

    UniProtKB/TrEMBL
    A0A5F4BXP2, A0A8C0LCQ3, A0A8C0TL48
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1069 → 1101
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

  5. XM_038426517.1 → XP_038282445.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

    UniProtKB/TrEMBL
    A0A5F4BXP2, A0A8C0LCQ3, A0A8C0TL48
    Conserved Domains (7) summary
    smart00209
    Location:550 → 602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239 → 454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:40 → 180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1069 → 1101
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:469 → 537
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:948 → 1002
    TSP1_ADAMTS; Thrombospondin type 1 domain

RNA

  1. XR_005297405.1 RNA Sequence

  2. XR_005297404.1 RNA Sequence

    Related
    ENSCAFT00845012334.1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    52820751..52836351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    53267203..53282791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    53498562..53514160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    52891920..52907521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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