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cd04273: ZnMc_ADAMTS_like 
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.
Statistics
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PSSM-Id: 239801
View PSSM: cd04273
Aligned: 43 rows
Threshold Bit Score: 231.359
Threshold Setting Gi: 25900857
Created: 30-Jun-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Comment:Based on similarity to sequences with known structures.

cd04273 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd04273 is a member of the superfamily cl00064.
cd00203:ZnMccd04267:ZnMc_ADAM_likecd04268:ZnMc_MMP_likecd04269:ZnMc_adamalysin_II_likecd04270:ZnMc_TACE_likecd04271:ZnMc_ADAM_fungalcd04272:ZnMc_salivary_gland_MPscd04273:ZnMc_ADAMTS_likecd04275:ZnMc_pappalysin_likecd04276:ZnMc_MMP_like_2cd04277:ZnMc_serralysin_likecd04278:ZnMc_MMPcd04279:ZnMc_MMP_like_1cd04280:ZnMc_astacin_likecd04281:ZnMc_BMP1_TLDcd04282:ZnMc_meprincd04283:ZnMc_hatching_enzymecd04327:ZnMc_MMP_like_355468618910762725074686111131170684354856650848820130265180301842481753425900857684369315075722555961033377907847204308437999850246399305075328211131377174329185076152572015828507538557680064768363864321304275075450956118266683689849300313838798829300307055249587126444836844030312643637126439034722686045553379552413369108476166516247665115685546861891076272507468611113117068435485665084882013026518030184248175342590085768436931507572255596103337790784720430843799985024639930507532821113137717432918507615257201582850753855768006476836386432130427507545095611826668368984930031383879882930030705524958712644483684403031264363712643903472268604555337955241336910847616651624766511568
cd04273 Sequence Cluster
cd04273 Sequence Cluster
Sub-family Hierarchy
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 cd04273 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 32130427  293 RFVEVLVVADnrmvs--------yhgeNLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQdgps----isfnA 360
gi 55468618  184 LWLELAIVADntmlk-------fhgreRVKHYILALMNIVSAIFNDPSLGSNITLVINKLFLYEDKDiilk-----ygnI 251
gi 50746861  572 YNIEVLLGVDdsvvr-------fhgkeHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKsisli---ergnP 641
gi 66508488 1542 LTLELALFFDetgynlfs-pffdrndeKILDMLLAYINGIQAVYHHPSLGIAIDISLVRLEIMQKQPedlph---hdgeR 1617
gi 20130265  286 LFIETAIFVDsdlyahmqknfptntesKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDppglv---rsrdV 362
gi 18030184  133 LTVELAVFADdamwdhfkkmygkaaeeNMHTFIMAVVNNIDVLYTQRLLQPRINIKIVRYEILKNIPhlmnarkhsngdV 212
gi 24817534  233 ITLEIGLFLDsklfehfereyiqdaeqHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPsalstgvhkngqA 312
gi 11131170  266 YNIEVLLGVDdsvvq-------fhgkeHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKsmsli---eignP 335
gi 68435485  284 FNIEVLLGVDcsvvm-------fhgreHIQKYLLTLMNIVNEIYQDSTLGAHINVVLVRIMMLCSSKsmgli---elgnA 353
gi 91076272  254 RWLEIALAVDhtliq-------fhgkdKVEQYVLALMNIVNAIYQDPSLEANMRLVVTRLLLYEHRKqsiv----rpgdA 322
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 32130427  361 QTTLKNFCQWQHSKNspgg----ihhDTAVLLTRQDIcra---hdkCDTLGLAELGTICdpYRSCSISEDs--------- 424
gi 55468618  252 KKSLEAINKWNYRHLmklpe-gstgwDATIWLTRSQL---------GGPSGFAPVGGVCtkTRSAAIDRDe--------- 312
gi 50746861  642 SRSLENVCRWAYQQQksdpn-hsehhDHAIFLTRQDFg-------pAGMQGYAPVTGMChpVRSCTLNHEd--------- 704
gi 66508488 1618 GKLLDSFCNYAKKNNpanef-npnhwDMGLYVSGLDFyvmeggqknSATMGLAIVNGLCieQYSCVIAELgvtnqfgkpf 1696
gi 20130265  363 ENYLNSFCKWQEKLNpfsda-dplhyDHALVLTGLDLvtydkgkanSQVVGMATVKGMCtsIYSCTINEAk--------- 432
gi 18030184  213 DRLLDAFCQYQNEINppnda-dprhwDHALLFSGYDLhrn----gvKTVAGYAPVKGMCsgVRSCTINEGl--------- 278
gi 24817534  313 QSLLDAFCRYQAHMNpgtdltdmnhyDHGVLLTGYDIyh-----ttTSVAGVAPVARMCdpLFACSLVEGl--------- 378
gi 11131170  336 SQSLENVCRWAYLQQkpdtg-hdeyhDHAIFLTRQDFg-------pSGMQGYAPVTGMChpVRSCTLNHEd--------- 398
gi 68435485  354 SQSLENVCRWAFLQQkedkn-daeyhDHAIFLTRQEFg-------pTGMQGYAPVTGMChpVRSCTLNHEd--------- 416
gi 91076272  323 KKSLENANSWNSRLHaslap-deshhDIAVWLTRSDI---------GGPSGYAPVAGACdpKRSCALNRDe--------- 383
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #     #                                                         
gi 32130427  425 ---gLSTAFTIAHELGHVFNMPHDDn----NKCKEegvkspQHVMAPTLnfytnpWMWSKCSRKYITEFLDtgy-----g 492
gi 55468618  313 ---gLTSAFVIAHELAHLLGLTHDGe----GNCQSea--lrGSVMAPTVlatlhnFAWSSCSKEQFHAKSKkw------- 376
gi 50746861  705 ---gFSSAFVVAHETGHVLGMEHDGq---gNRCGDet--amGSVMAPLVqaafhrYHWSRCSGQELKRYIHsy------- 769
gi 66508488 1697 psagFTSIYVAAHEMGHNLGMHHDSt---gNTCPKd-----GYIMSPSRgiy-geTIWSECSREVAQKLPYtk------- 1760
gi 20130265  433 ---hFESVFVVAHEIGHNLGMRHDAk---eISCDPt-----MHIMSPKLgs--gkVTWSKCSRTYLEDFLMdpq-----a 494
gi 18030184  279 ---dFGSVFVVTHEMGHSLGMYHDGd----NECDLr-----CCIMSPSVgs--gkTHWSQCSVNEMATFVGhlgddfrpp 344
gi 24817534  379 ---hLGRSFVLAHEMGHNMGMVHDGv---qNQCNKg-----CCLMSAVNga--gkTTWSDCSVREFNAFLLqldes-grg 444
gi 11131170  399 ---gFSSAFVVAHETGHVLGMEHDGq---gNRCGDev--rlGSIMAPLVqaafhrFHWSRCSQQELSRYLHsy------- 463
gi 68435485  417 ---gFSSAFVVAHETGHVLGMEHDGq---aNECGDev--pmGSIMAPLVqaafhrFHWSRCSQQELRRYLNty------- 481
gi 91076272  384 ---gLTSAFIIAHEMAHVLGLSHDGdkkhsNHCGDes--akGSVMAPLVaatfhqFFWSQCSRKEFKKIVKkw------- 451

                 ....
Feature 1            
gi 32130427  493 eCLL 496
gi 55468618  377 wCLH 380
gi 50746861  770 dCLL 773
gi 66508488 1761 sCLR 1764
gi 20130265  495 eCLF 498
gi 18030184  345 nCLQ 348
gi 24817534  445 nCLR 448
gi 11131170  464 dCLL 467
gi 68435485  482 dCLR 485
gi 91076272  452 tCLS 455

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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