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PANX1 pannexin 1 [ Canis lupus familiaris (dog) ]

Gene ID: 607532, updated on 5-Mar-2024

Summary

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Official Symbol
PANX1provided by VGNC
Official Full Name
pannexin 1provided by VGNC
Primary source
VGNC:VGNC:44254
See related
Ensembl:ENSCAFG00845020558
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PANX1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (6846046..6895302, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (6675643..6724808, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (6746177..6795582, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (6626593..6676016, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (6695903..6745264, complement)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102151931 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene hephaestin like 1 Neighboring gene cardiolipin synthase (CMP-forming)-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Destination and consequences of Panx1 and mutant expression in polarized MDCK cells. Shum MG, et al. Exp Cell Res, 2019 Aug 15. PMID 31102595
  2. Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation. Dolmatova E, et al. Am J Physiol Heart Circ Physiol, 2012 Nov 15. PMID 22982782, Free PMC Article
  3. Pannexin channels increase propidium iodide permeability in frozen-thawed dog spermatozoa. Torres JL, et al. Reprod Fertil Dev, 2017 Oct. PMID 28390472
  4. Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. Ambrosi C, et al. J Biol Chem, 2010 Aug 6. PMID 20516070, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Panx1 is preferentially delivered to the apical domain of polarized epithelial cells, and Panx1 mutants drive phenotypic changes to MDCK cells preventing their polarization.
    Title: Destination and consequences of Panx1 and mutant expression in polarized MDCK cells.
  2. All three Panx proteins were found in dog spermatozoa: Panx1 was mostly localised to the acrosomal and equatorial segment, Panx2 was found in the posterior region of the head and tail and Panx3 was localised to the equatorial and posterior head segment.
    Title: Pannexin channels increase propidium iodide permeability in frozen-thawed dog spermatozoa.
  3. ATP release through Panx1 channels in cardiac myocytes during ischemia may be an early paracrine event leading to profibrotic responses to ischemic cardiac injury.
    Title: Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.
  4. Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other
    Title: Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-1 production IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pannexin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    6846046..6895302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429756.1 → XP_038285684.1  pannexin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PDQ2
    Related
    ENSCAFP00845028331.1, ENSCAFT00845036209.1
    Conserved Domains (1) summary
    cl11443
    Location:233 → 338
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  2. XM_038429757.1 → XP_038285685.1  pannexin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P4Z6
    Related
    ENSCAFP00845028383.1, ENSCAFT00845036270.1
    Conserved Domains (1) summary
    cl11443
    Location:193 → 298
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  3. XM_038429758.1 → XP_038285686.1  pannexin-1 isoform X3

    Conserved Domains (1) summary
    cl11443
    Location:175 → 280
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    6626593..6676016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038505168.1 → XP_038361096.1  pannexin-1 isoform X1

    Conserved Domains (1) summary
    cl11443
    Location:233 → 338
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  2. XM_038505169.1 → XP_038361097.1  pannexin-1 isoform X2

    Conserved Domains (1) summary
    cl11443
    Location:193 → 298
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  3. XM_038505170.1 → XP_038361098.1  pannexin-1 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    6695903..6745264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038632441.1 → XP_038488369.1  pannexin-1 isoform X1

  2. XM_038632443.1 → XP_038488371.1  pannexin-1 isoform X2

  3. XM_038632444.1 → XP_038488372.1  pannexin-1 isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    6746177..6795582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038568297.1 → XP_038424225.1  pannexin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KW36, A0A8C0T182, A0A8P0S9S8
    Conserved Domains (1) summary
    cl11443
    Location:233 → 338
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  2. XM_038568298.1 → XP_038424226.1  pannexin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SZT2, A0A8P0PE67
    Conserved Domains (1) summary
    cl11443
    Location:193 → 298
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  3. XM_038568300.1 → XP_038424228.1  pannexin-1 isoform X3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    6675643..6724808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_844236.5 → XP_849329.1  pannexin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KW36, A0A8C0T182, A0A8P0S9S8
    Conserved Domains (1) summary
    cl11443
    Location:233 → 338
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  2. XM_038456348.1 → XP_038312276.1  pannexin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SZT2, A0A8P0PE67
    Conserved Domains (1) summary
    cl11443
    Location:193 → 298
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

  3. XM_005633358.4 → XP_005633415.1  pannexin-1 isoform X3

    Conserved Domains (1) summary
    cl11443
    Location:175 → 280
    Cas6-I-III; CRISPR/Cas system-associated RAMP superfamily protein Cas6
Nucleotide Protein
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