SENP2 SUMO specific peptidase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SENP2provided by HGNC
Official Full Name: SUMO specific peptidase 2provided by HGNC
Primary source: HGNC:HGNC:23116
See related: Ensembl:ENSG00000163904 MIM:608261; AllianceGenome:HGNC:23116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AXAM2; SMT3IP2
Summary: SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
Expression: Broad expression in testis (RPKM 37.1), brain (RPKM 13.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q27.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (185586295..185633551)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (188402099..188449380)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (185304083..185351339)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
Title: Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.
SENP2 regulates mitochondrial function and insulin secretion in pancreatic beta cells.
Title: SENP2 regulates mitochondrial function and insulin secretion in pancreatic β cells.
Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
Title: Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-kappaB Through the Modulation of IkappaBalpha Sumoylation.
Title: Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation.
Overexpression of SENP2 was correlated with a better overall survival of the Gastric Cancer patients with a marginally significance, indicating that SENP2 expression could be used as a novel biomarker to predict patient prognosis.
Title: Comprehensive Analysis of the Canonical and Non-canonical Wnt Signaling Pathways in Gastric Cancer.
SENP2 regulates its substrate for desumoylation, and also the role of SENP2 in TGF-beta induced cancer cell migration.
Title: The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis.
he nuclear factor (NF)kappaB signaling pathway was also regulated by the overexpression of SENP2. On the whole, the findings of this study indicate tha SENP2 can act as a tumor suppressor in CLL cells, and may thus prove to be a novel target for CLL treatment in clinical practice.
Title: SENP2 exerts an anti‑tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF‑κB signaling pathways.
SENP2 is amplified as part of the chromosome 3q amplification in many cancers and Increased SENP2 expression prolongs MDC1 focus retention and increases NHEJ and radioresistance
Title: The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.
SENP2 binds to intracellular membranes where it interacts with membrane-associated proteins and has the potential to regulate their sumoylation and membrane-associated functions.
Title: The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-terminal amphipathic α-helix.
research achievements of SENP2 are reviewed in order to understand its related functions and the underlying molecular mechanisms and provide a clue for future research on SENP2
Title: SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-24167 (e-PCR)
- UniSTS:59211

D3S3113 (e-PCR)
- UniSTS:71812

RH92734 (e-PCR)
- UniSTS:88765

Cda0da04 (e-PCR)
- UniSTS:38382

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SUMO-specific endopeptidase activity	EXP Inferred from Experiment more info	PubMed
enables SUMO-specific endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	TAS Traceable Author Statement more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sentrin-specific protease 2

Names: SMT3-specific isopeptidase 2; SUMO1/sentrin/SMT3 specific peptidase 2; SUMO1/sentrin/SMT3 specific protease 2; sentrin (SUMO1) specific peptidase 2; sentrin/SUMO-specific protease SENP2

NP_067640.2

EC 3.4.22.68

XP_005247747.2

EC 3.4.22.68

XP_005247748.1

EC 3.4.22.68

XP_054203397.1

EC 3.4.22.68

XP_054203398.1

EC 3.4.22.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021627.3 → NP_067640.2 sentrin-specific protease 2

See identical proteins and their annotated locations for NP_067640.2

Status: VALIDATED

Source sequence(s)

AC016961, AF151697, AL834380, BC018020, BC040609

Consensus CDS

CCDS33902.1

UniProtKB/Swiss-Prot

B4DQ42, Q8IW97, Q96SR2, Q9HC62, Q9P2L5

UniProtKB/TrEMBL

B4E2S4

Related

ENSP00000296257.5, ENST00000296257.10

Conserved Domains (1) summary

COG5160
Location:384 → 589

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

185586295..185633551

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005247690.4 → XP_005247747.2 sentrin-specific protease 2 isoform X1

UniProtKB/TrEMBL

B4E2S4

Conserved Domains (1) summary

cl23802
Location:370 → 540

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
XM_005247691.4 → XP_005247748.1 sentrin-specific protease 2 isoform X2

UniProtKB/TrEMBL

B4DKY9

Conserved Domains (1) summary

cl23802
Location:221 → 469

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain