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Senp2 SUMO/sentrin specific peptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 75826, updated on 21-Apr-2024

Summary

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Official Symbol
Senp2provided by MGI
Official Full Name
SUMO/sentrin specific peptidase 2provided by MGI
Primary source
MGI:MGI:1923076
See related
Ensembl:ENSMUSG00000022855 AllianceGenome:MGI:1923076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SuPr-1; Smt3ip2; mKIAA1331; 2310007L05Rik; 4930538C18Rik
Summary
Enables SUMO-specific isopeptidase activity. Involved in fat cell differentiation and protein desumoylation. Acts upstream of or within several processes, including embryonic placenta development; negative regulation of DNA damage response, signal transduction by p53 class mediator; and regulation of cell cycle process. Located in cytoplasmic vesicle and nuclear body. Colocalizes with PML body. Is expressed in several structures, including blastocyst; central nervous system; early embryo; extraembryonic component; and retina. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 18.7), placenta adult (RPKM 14.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B1; 16 12.98 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21828182..21868019)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22009432..22049269)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40374 Neighboring gene transmembrane protein 41a Neighboring gene lipase, member H Neighboring gene STARR-seq mESC enhancer starr_40375 Neighboring gene STARR-seq mESC enhancer starr_40377 Neighboring gene STARR-seq mESC enhancer starr_40378 Neighboring gene STARR-positive B cell enhancer ABC_E393 Neighboring gene STARR-seq mESC enhancer starr_40381 Neighboring gene NADH:ubiquinone oxidoreductase subunit A11B Neighboring gene insulin-like growth factor 2 mRNA binding protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:22108158-22108341 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:22131539-22131740 Neighboring gene STARR-seq mESC enhancer starr_40384

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis. Yang TT, et al. Commun Biol, 2023 Jun 10. PMID 37301920, Free PMC Article
  2. Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes. Kim PC, et al. Diabetes Metab J, 2023 May. PMID 36872063, Free PMC Article
  3. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Dufour D, et al. Nat Commun, 2022 Dec 21. PMID 36543805, Free PMC Article
  4. The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα. Dou X, et al. J Biol Chem, 2022 Feb. PMID 34971706, Free PMC Article
  5. Cardiomyocyte-specific deletion of Senp2 contributes to CVB3 viral replication and inflammation. Wang K, et al. Int Immunopharmacol, 2020 Nov. PMID 33182061

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury.
    Title: SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury.
  2. SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis.
    Title: SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis.
  3. Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes.
    Title: Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes.
  4. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.
    Title: Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.
  5. SENP2-PLCbeta4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
    Title: SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
  6. The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKalpha.
    Title: The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα.
  7. SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPbeta.
    Title: SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ.
  8. Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
    Title: Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
  9. Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
    Title: Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
  10. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
    Title: The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1331

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deSUMOylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in dorsal/ventral axis specification ISO
Inferred from Sequence Orthology
more info
  
involved_in fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within labyrinthine layer development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein desumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spongiotrophoblast layer development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sentrin-specific protease 2
Names
SUMO-1 protease-1
SUMO-1/Smt3-specific isopeptidase 2
SUMO/sentrin specific protease 2
axam2
sentrin/SUMO-specific protease SENP2
NP_001344353.1
NP_083733.1
XP_006522751.1
XP_006522752.1
XP_030105183.1
XP_030105184.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357424.1 → NP_001344353.1  sentrin-specific protease 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009567, CT030725
    Conserved Domains (1) summary
    COG5160
    Location:302 → 507
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  2. NM_029457.3 → NP_083733.1  sentrin-specific protease 2 isoform 1

    See identical proteins and their annotated locations for NP_083733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK031030, CJ169147, CT009567, CT030725
    Consensus CDS
    CCDS28065.1
    UniProtKB/Swiss-Prot
    Q544T8, Q811R3, Q91ZX6, Q9D4Z0
    Related
    ENSMUSP00000023561.8, ENSMUST00000023561.8
    Conserved Domains (1) summary
    cl23802
    Location:337 → 583
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RNA

  1. NR_027488.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF368904, AK031030, CJ169147, CT009567, CT030725

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    21828182..21868019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522688.3 → XP_006522751.1  sentrin-specific protease 2 isoform X1

    Conserved Domains (1) summary
    COG5160
    Location:388 → 593
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  2. XM_006522689.5 → XP_006522752.1  sentrin-specific protease 2 isoform X3

    Conserved Domains (1) summary
    COG5160
    Location:341 → 546
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  3. XM_030249324.2 → XP_030105184.1  sentrin-specific protease 2 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:307 → 512
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  4. XM_030249323.2 → XP_030105183.1  sentrin-specific protease 2 isoform X2

    Conserved Domains (1) summary
    COG5160
    Location:379 → 584
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

RNA

  1. XR_003951844.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZX6.2 GenPept UniProtKB/Swiss-Prot:Q91ZX6

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