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dazl deleted in azoospermia-like [ Danio rerio (zebrafish) ]

Gene ID: 58039, updated on 27-Mar-2024

Summary

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Official Symbol
dazlprovided by ZNC
Official Full Name
deleted in azoospermia-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000405-6
See related
Ensembl:ENSDARG00000036214 AllianceGenome:ZFIN:ZDB-GENE-000405-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables mRNA 3'-UTR binding activity; sequence-specific DNA binding activity; and translation activator activity. Acts upstream of or within 3'-UTR-mediated mRNA stabilization and negative regulation of gene silencing by miRNA. Located in cytoplasm. Is expressed in blastodisc; gonad; unfertilized egg; and yolk. Orthologous to several human genes including DAZL (deleted in azoospermia like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See dazl in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20389104..20403871, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20804781..20819548, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene raftlin, lipid raft linker 1a Neighboring gene TBC1 domain family, member 5 Neighboring gene SATB homeobox 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Methods for the analysis of early oogenesis in Zebrafish. Elkouby YM, et al. Dev Biol, 2017 Oct 15. PMID 27988227, Free PMC Article
  2. Zebrafish DAZ-like protein controls translation via the sequence 'GUUC'. Maegawa S, et al. Genes Cells, 2002 Sep. PMID 12296827
  3. Multigenerational consequences of early-life cannabinoid exposure in zebrafish. Carty DR, et al. Toxicol Appl Pharmacol, 2019 Feb 1. PMID 30594692, Free PMC Article
  4. High-Sensitivity and High-Resolution In Situ Hybridization of Coding and Long Non-coding RNAs in Vertebrate Ovaries and Testes. Takei N, et al. Biol Proced Online, 2018. PMID 29507535, Free PMC Article
  5. Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. Escobar-Aguirre M, et al. PLoS Genet, 2017 Sep. PMID 28880872, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition.
    Title: Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition.
  2. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl, in the zebrafish embryo have been presented.
    Title: Cortical depth and differential transport of vegetally localized dorsal and germ line determinants in the zebrafish embryo.
  3. that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.
    Title: HuB (elavl2) mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL.
  4. DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish
    Title: DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish.
  5. Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates.
    Title: Zebrafish DAZ-like protein controls translation via the sequence 'GUUC'.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within oogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
deleted in azoospermia-like
Names
DAZ-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131524.1 → NP_571599.1  deleted in azoospermia-like

    See identical proteins and their annotated locations for NP_571599.1

    Status: PROVISIONAL

    Source sequence(s)
    AB018191
    UniProtKB/Swiss-Prot
    Q9YGW7
    Related
    ENSDARP00000113712.1, ENSDART00000137590.3
    Conserved Domains (2) summary
    COG0724
    Location:40 → 132
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12672
    Location:42 → 123
    RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    20389104..20403871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170071.3 → XP_005170128.1  deleted in azoospermia-like isoform X2

    See identical proteins and their annotated locations for XP_005170128.1

    UniProtKB/TrEMBL
    A0A8M2BHE4, Q1LUN5
    Conserved Domains (2) summary
    COG0724
    Location:23 → 115
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12672
    Location:25 → 106
    RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

  2. XM_005170072.4 → XP_005170129.1  deleted in azoospermia-like isoform X2

    See identical proteins and their annotated locations for XP_005170129.1

    UniProtKB/TrEMBL
    A0A8M2BHE4, Q1LUN5
    Related
    ENSDARP00000121099.1, ENSDART00000147911.3
    Conserved Domains (2) summary
    COG0724
    Location:23 → 115
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12672
    Location:25 → 106
    RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins

  3. XM_005170070.4 → XP_005170127.1  deleted in azoospermia-like isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHE7, Q1LUN6
    Related
    ENSDARP00000052602.3, ENSDART00000052603.5
    Conserved Domains (2) summary
    COG0724
    Location:40 → 132
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12672
    Location:42 → 123
    RRM_DAZL; RNA recognition motif in vertebrate deleted in azoospermia-like (DAZL) proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9YGW7.1 GenPept UniProtKB/Swiss-Prot:Q9YGW7

Gene LinkOut

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