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ADGRB2 adhesion G protein-coupled receptor B2 [ Homo sapiens (human) ]

Gene ID: 576, updated on 26-May-2016
Official Symbol
ADGRB2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B2provided by HGNC
Primary source
HGNC:HGNC:944
See related
Ensembl:ENSG00000121753 HPRD:04063; MIM:602683; Vega:OTTHUMG00000003885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI2
Summary
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Orthologs
Location:
1p35
Exon count:
33
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (31727105..31764063, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32192718..32230494, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378628 Neighboring gene uncharacterized LOC101929444 Neighboring gene collagen type XVI alpha 1 Neighboring gene microRNA 4254 Neighboring gene SPOC domain containing 1 Neighboring gene protein tyrosine phosphatase type IVA, member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adhesion G protein-coupled receptor B2
Names
brain-specific angiogenesis inhibitor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294335.1NP_001281264.1  adhesion G protein-coupled receptor B2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001281264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AB005298, AC114488, AI291691, DA494051
    Consensus CDS
    CCDS72747.1
    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000362759, OTTHUMP00000003957, ENST00000373655, OTTHUMT00000011084
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:606772
    DUF3497; Domain of unknown function (DUF3497)
  2. NM_001294336.1NP_001281265.1  adhesion G protein-coupled receptor B2 isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB005298, AC114488, AI291691, BC136533, DA494051
    Consensus CDS
    CCDS72746.1
    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000435397, OTTHUMP00000228425, ENST00000527361, OTTHUMT00000381841
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:606772
    DUF3497; Domain of unknown function (DUF3497)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    31727105..31764063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541854.1XP_011540156.1  

    Related
    ENSP00000381555, OTTHUMP00000195041, ENST00000398547, OTTHUMT00000313756
    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:551717
    DUF3497; Domain of unknown function (DUF3497)
  2. XM_011541850.1XP_011540152.1  

    Related
    ENSP00000381548, OTTHUMP00000195042, ENST00000398538, OTTHUMT00000313757
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:606772
    DUF3497; Domain of unknown function (DUF3497)
  3. XM_011541856.1XP_011540158.1  

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741110
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:551717
    DUF3497; Domain of unknown function (DUF3497)
  4. XM_011541849.1XP_011540151.1  

    See identical proteins and their annotated locations for XP_011540151.1

    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000381550, OTTHUMP00000195040, ENST00000398542, OTTHUMT00000313755
    Conserved Domains (5) summary
    smart00303
    Location:858911
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:519583
    HormR; Domain present in hormone receptors
    smart00209
    Location:355405
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9171186
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:594760
    DUF3497; Domain of unknown function (DUF3497)
  5. XM_011541858.1XP_011540160.1  

    Conserved Domains (5) summary
    smart00303
    Location:567620
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:228292
    HormR; Domain present in hormone receptors
    smart00209
    Location:64114
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:626895
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:303469
    DUF3497; Domain of unknown function (DUF3497)
  6. XM_011541853.1XP_011540155.1  

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:551717
    DUF3497; Domain of unknown function (DUF3497)
  7. XM_011541851.1XP_011540153.1  

    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:606772
    DUF3497; Domain of unknown function (DUF3497)
  8. XM_011541848.1XP_011540150.1  

    See identical proteins and their annotated locations for XP_011540150.1

    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000362762, ENST00000373658
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:606772
    DUF3497; Domain of unknown function (DUF3497)
  9. XM_011541857.1XP_011540159.1  

    Conserved Domains (5) summary
    smart00303
    Location:760813
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:421485
    HormR; Domain present in hormone receptors
    smart00209
    Location:368418
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8191088
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:496662
    DUF3497; Domain of unknown function (DUF3497)
  10. XM_011541855.1XP_011540157.1  

    Related
    ENSP00000381564, OTTHUMP00000195038, ENST00000398556, OTTHUMT00000313753
    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741110
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:551717
    DUF3497; Domain of unknown function (DUF3497)
  11. XM_011541852.1XP_011540154.1  

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:314362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:551717
    DUF3497; Domain of unknown function (DUF3497)
  12. XM_011541859.1XP_011540161.1  

    Conserved Domains (3) summary
    smart00303
    Location:262315
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam00002
    Location:321590
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam12003
    Location:1164
    DUF3497; Domain of unknown function (DUF3497)

RNA

  1. XR_946719.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    32308501..32345459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001703.2: Suppressed sequence

    Description
    NM_001703.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.