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    BAI2 brain-specific angiogenesis inhibitor 2 [ Homo sapiens (human) ]

    Gene ID: 576, updated on 12-May-2013
    Official Symbol
    BAI2provided by HGNC
    Official Full Name
    brain-specific angiogenesis inhibitor 2provided by HGNC
    Primary source
    HGNC:944
    Locus tag
    RP11-73M7.7
    See related
    Ensembl:ENSG00000121753; HPRD:04063; MIM:602683; Vega:OTTHUMG00000003885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
    Location :
    1p35
    Sequence :
    Chromosome: 1; NC_000001.10 (32192718..32229648, complement)
    See BAI2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene penta-EF-hand domain containing 1 Neighboring gene collagen, type XVI, alpha 1 Neighboring gene microRNA 4254 Neighboring gene SPOC domain containing 1 Neighboring gene protein tyrosine phosphatase type IVA, member 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. Zencir S, et al. Biochem Biophys Res Commun, 2011 Aug 12. PMID 21787750.
    2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
    3. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. Okajima D, et al. J Recept Signal Transduct Res, 2010 Jun. PMID 20367554.
    4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
    5. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. Jeong BC, et al. FEBS Lett, 2006 Jan 23. PMID 16412436.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This is the first study reporting BAI2 as an interaction partner of GIP.
      Title: Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    3. BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway
      Title: Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing.
    4. involvement of BAI2 in the ischemia-induced brain angiogenesis
      Title: Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001694.1 NP_821074.1 STARD13    BIND  PubMed STARD13 (RhoGAP) interacts with BAI2. 
    O60241 Q07960 ARHGAP1    HPRD  PubMed  
    O60241 Q06547 GABPB1    HPRD  PubMed  
    O60241 Haloacid dehalogenase like hydrolase domain containing 2 HDHD2    HPRD  PubMed  
    O60241 Megalin binding protein LRP2BP    HPRD  PubMed  
    O60241 Q9Y566 SHANK1    HPRD  PubMed  
    O60241 Q9UPX8 SHANK2    HPRD  PubMed  
    O60241 Q9Y3M8 STARD13    HPRD  PubMed  
    BioGRID:107052 BioGRID:119171 SHANK1    BioGRID  PubMed Two-hybrid 
    BioGRID:107052 BioGRID:124744 STARD13    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    peripheral nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    brain-specific angiogenesis inhibitor 2
    Names
    brain-specific angiogenesis inhibitor 2
    Brain-specific angiongenesis inhibitor-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001703.2 → NP_001694.2  brain-specific angiogenesis inhibitor 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AB005298, BC009035, BE379230, DA314854
      Consensus CDS
      CCDS346.2
      UniProtKB/Swiss-Prot
      O60241
      Related
      ENSP00000362762, OTTHUMP00000228424, ENST00000373658, OTTHUMT00000381838
      Conserved Domains (5) summary
      smart00008
      Location:531 – 595
      Blast Score: 121
      HormR; Domain present in hormone receptors
      smart00209
      Location:314 – 362
      Blast Score: 149
      TSP1; Thrombospondin type 1 repeats
      smart00303
      Location:870 – 923
      Blast Score: 162
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam00002
      Location:929 – 1198
      Blast Score: 587
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam12003
      Location:606 – 863
      Blast Score: 441
      DUF3497; Domain of unknown function (DUF3497)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      32192718..32229648, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      30310212..30346996, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      32272135..32309067, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AB065648.1 BAC05874.1
    genomic ABBA01023452.1 (41..21038) None
    genomic ABBA01023453.1 None
    genomic AC114488.3 (162402..184854) None
    genomic AL354919.16 (2001..16478) None
    genomic AMYH01000460.1 (190083..227015) None
    genomic CH471059.2 EAX07589.1
      EAX07590.1
      EAX07591.1
      EAX07592.1
      EAX07593.1
      EAX07594.1
    mRNA AB005298.1 BAA25362.1
    mRNA AK123392.1 None
    mRNA AK294361.1 BAG57625.1
    mRNA AK294999.1 BAG58063.1
    mRNA AK296502.1 BAG59135.1
    mRNA AK307805.1 None
    mRNA BC009035.1 AAH09035.1
    mRNA BC014780.1 None
    mRNA BC136533.1 AAI36534.1
    mRNA BE379230.1 None
    mRNA DA314854.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60241.2 GenPept UniProtKB/Swiss-Prot:O60241

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
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        Link from Gene to dbVar
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        Link to related EST entry
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        Full text in PubMedCentral identified from shared sequence links
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        Genome records having the gene annotated on corresponding genomic reference sequence.
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        Link to related Nucleotide entry
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        Related Probe entry
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        Link to related protein entry
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        PubChem Substances
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        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
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        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
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        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
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        SNPs linked from GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
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        Related UniSTS records

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